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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

  2. 1. Engineering Yeast Metabolism for Production of Sesquiterpenes

    Author : Stefan Tippmann; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Saccharomyces cerevisiae; affibodies; transcriptomics; isoprenoids; sesquiterpenes; metabolomics; metabolic engineering;

    Abstract : Sesquiterpenes belong to the large and diverse group of isoprenoids, which are ubiquitous in the plant kingdom and have various applications in the chemical industry as fragrances, pharmaceuticals and as substitutes for petroleum-based gasoline, diesel and jet fuels. In this project, production of sesquiterpenes was studied in Saccharomyces cerevisiae using farnesene as an example with the objective to gain new insights into the synthesis of these compounds and to evaluate different metabolic engineering strategies. READ MORE

  4. 2. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy

    Author : Astrid Henz Ryen; Anders Backlund; Thierry Kogej; Fernando B. Da Costa; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; angiosperm chemistry; physicochemical properties of plant specialized metabolites; chemical diversity; chemical space; sesquiterpene lactones; scaffold diversity; molecular framework; cluster analysis; ECFP6; Lindera benzoin; sesquiterpenes; anti-inflammatory; Farmakognosi; Pharmacognosy;

    Abstract : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. READ MORE

  5. 3. Metabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene Production

    Author : Gionata Scalcinati; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Systems Biology; Saccharomyces cerevisiae.; Evolutionary engineering; Metabolic Engineering; Microrefinery; Cell factory; Synthetic Biology;

    Abstract : Industrial biotechnology aims to develop robust “microbial cell factories”, to produce an array of added value chemicals presently dominated by petrochemical processes. The exploitation of an efficient microbial production as sustainable technology has an important impact for our society. READ MORE

  6. 4. Characterization of Secondary Metabolites from Natural Sources

    Author : Gilda Erosa; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bourreria pulchra; Heliotropium angiospermum; medicinal plants; Cylindrocarpon; Ripartites metrodii; natural products; Ripartites tricholoma; Sideroxylon foetidissimum.;

    Abstract : Natural products have contributed for many years to the development of new medicines for the treatment of diseases. Their structural diversity and complexity have inspired chemists to produce interesting compounds with pharmaceutical use. READ MORE

  7. 5. Natural Products from Cameroonian Medicinal Plants

    Author : Apollinaire Tsopmo; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; Plant biochemistry; antiplasmodial.; antitrypanosomal; diarylheptanoids; terpenoids; flavonoids; aframodial; Aframomum; Reneilmia cincinnata; Dorstenia; Euphorbia; Lepidobotrys staudtii; Pentadiplandra brazzeanea; Vernonia guineensis; Natural products; Myrica arborea;

    Abstract : Natural product chemistry is a main research area in Cameroon, as well as for the division of Bioorganic Chemistry at Lund Institute of Technology. A review of the results obtained recently with Cameroonian medicinal plants shows that a large number of compounds, many with complex structures, have been isolated and characterised, and the work presented in this thesis is part of this effort. READ MORE