Search for dissertations about: "shRNA"

Showing result 1 - 5 of 35 swedish dissertations containing the word shRNA.

2. 1. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

   Author : Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

   Abstract : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. READ MORE

4. 2. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

   Author : Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

   Abstract : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. READ MORE

5. 3. Pre- and postsynaptic dysregulation of dopamine signalling in Parkinson's disease

   Author : Gurdal Sahin; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Keywords : [18F]fallypride; 3-OMD; AAV; blood-brain barrier; dyskinesia; HVA; L-DOPA; microdialysis; modeling; Parkinson’s disease; pharmacokinetics; positron-emission tomography; prediction; RNA interference; shRNA;

   Abstract : .... READ MORE

6. 4. Molecular dissection of Bruton’s tyrosine kinase signaling in hematopoietic cells using RNAi

   Author : Juhana E Heinonen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : RNA mediated gene silencing, RNA interference (RNAi), has recently been identified in mammalians. This thesis describes the utilization and development of RNAi based tools for signal transduction research. The effects of Bruton s tyrosine kinase (Btk) down-regulation with RNAi have been studied with gene expression profiling in hematopoietic cells. READ MORE

7. 5. Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia

   Author : Aditya Harisankar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current treatment options for GBM lack specificity and result in severe side effects. READ MORE