Search for dissertations about: "short tandem repeat"

Found 5 swedish dissertations containing the words short tandem repeat.

2. 1. Evolutionary genomics in Corvids : – From single nucleotides to structural variants

   Author : Matthias H. Weissensteiner; Jochen B.W. Wolf; Manfred Grabherr; Kateryna M. Makova; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolutionary genetics; genomics; population genetics; selection; recombination; chromosomal features; colouration; insertion; deletion; inversion; crow; tandem repeat; transposable element; gene expression;

   Abstract : Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations. READ MORE

4. 2. Parallel target selection by trinucleotide threading

   Author : Pawel Zajac; Joakim Lundeberg; Afshin Ahmadian; Mats Nilsson; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; trinucleotide threading; multiplex amplification; expression profiling; microarray; generic tag; short tandem repeat; microsatellite; electrophoresis; single nucleotide polymorphism; allelotyping; 454; Pyrosequencing; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

   Abstract : DNA is the code for all life. Via intermediary RNA the information encoded by the genome is relayed to proteins executing the various functions in a cell. Together, this repertoire of inherently linked biological macromolecules determines all characteristics and features of a cell. READ MORE

5. 3. Assessing the structural and dynamical properties of concentrated solutions of the disordered proteins Histatin 5 and its tandem repeat

   Author : Eric Fagerberg; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Simulation; IDP; crowding;

   Abstract : Intrinsically disordered proteins are distinguished by a lack of distinct three-dimensional structure, existing instead as an ensemble of heterogenous structures. In this research, the effect of crowding on these proteins is investigated using a combined approach of experiment and computer simulation, mainly using coarse-grained simulation models to make simulation computationally feasible at the high concentration conditions crowding is displayed. READ MORE

6. 4. Repetitive DNA in search of a function - a study of telomeric and centromeric sequences in Chironomus

   Author : Casimiro Castillejo-Lopez; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chironomus; CENP-B box; mobile elements; reverse transcriptase; gene conversion; satellite; repetitive DNA; Telomere; centromere; Genetics; cytogenetics; Genetik; cytogenetik;

   Abstract : Repetitive DNA is quantitatively the main component of telomeres and centromeres, structures responsible for maintenance of the eukaryotic chromosome. The telomere is the specialized nucleoprotein complex that terminates linear chromosomes. READ MORE

7. 5. Methods and applications in DNA sequence alignments

   Author : Ellen Sherwood; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA sequence alignment; CNV; Chicken; Trypanosoma cruzi.;

   Abstract : DNA sequence alignment is one of the most common bioinformatics tasks. Alignment analysis for eukaryotic genomes is challenging because the datasets are large. Repeat sequences also make the analysis difficult. This thesis describes new methods which we have developed for DNA sequence alignment that address these problems. READ MORE