Search for dissertations about: "short-lived radionuclide"

Found 5 swedish dissertations containing the words short-lived radionuclide.

  2. 1. Liquid Chromatography – Mass Spectrometry Analysis of Short-lived Tracers in Biological Matrices : Exploration of Radiotracer Chemistry as an Analytical Tool

    Author : Martin Lavén; Karin Markides; Bengt Långström; Rolf Ekman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; liquid chromatography - mass spectrometry; radiotracer chemistry; positron emission tomography; biological samples; radionuclide imaging; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Liquid chromatography – mass spectrometry (LC-MS) methods were developed for the analysis of positron emission tomography (PET) radiotracers in biological matrices. Additionally, radiotracer chemistry was explored as an analytical tool for supporting LC-MS method development and imaging molecular interactions in miniaturised chemical analysis systems. READ MORE

  4. 2. Design and Evaluation of Radiolabeled Affibody Tracers for Imaging of HER2-expressing Tumors

    Author : Helena Wållberg; Stefan Ståhl; Dario Neri; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; radionuclide molecular imaging; HER2; radiotracer; SPECT; PET; biodistribution; protein engineering; radiolabeling;

    Abstract : The growing understanding of tumor biology and the identification of tumor specificgenetic and molecular alterations, such as the overexpression of human epidermal growthfactor receptor 2 (HER2), opens up for personalization of patient management using targeted therapies. However, this puts stringent demands on the diagnostic tools usedto identify patients that are likely to respond to a particular treatment. READ MORE

  5. 3. Quantitative imaging with PET : performance and applications of 76Br, 52Fe, 110mIn and 134La

    Author : Mark Lubberink; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PET; Positron Emission Tomography; Quantitative Imaging; bromine; iron; indium; lanthanum; Onkologi; Oncology; Onkologi; Oncology; Onkologi;

    Abstract : The use of positron emission tomography (PET) has so far mainly been limited to a few nuclides with short half-lives such as 11C and 18F. Certain applications require nuclides with longer half-lives, such as 76Br and 52Fe. READ MORE

  6. 4. Development and Applications of some Radioanalytical Procedures: Analysis of β- and α-Emitting Radionuclides Using Radiometric and ICP-MS Detection Methods

    Author : Henrik Ramebäck; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; diffusion; plutonium; 90Sr; curium; uranium; 99Tc; bentonite clay; analysis; UO2 fuel; leaching; americium; neptunium;

    Abstract : Analyses of radionuclides are important in environmental monitoring and in research. However, as in the analysis of many other species, interferences may be a problem. In a-spectrometric detection, 238Pu interferes with 241Am, owing to their similar decay energies. READ MORE

  7. 5. Method development for [11C]carbon monoxide radiochemistry

    Author : Mélodie Ferrat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is a biologically relevant molecule, labeled with a short-lived radionuclide. READ MORE