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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

2. 1. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

   Author : Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

   Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

4. 2. Idiopathic environmental intolerance attributed to electromagnetic fields : physiological and psychological aspects

   Author : Amanda Johansson; Lena Hillert; Umeå universitet; []
   Keywords : electrical hypersensitivity; EHS; mobile phone; MP; heart rate variability; HRV; provocation study; radiofrequency field; Occupational and Environmental Medicine; arbets- och miljömedicin;

   Abstract : This thesis aims to increase the knowledge on people with symptoms attributed to electromagnetic fields (EMF) by investigating the effects of EMF exposure and by additional description of the heterogeneous group of people reporting EMF-related symptoms. The effect of mobile phone (MP)-like radio frequency (RF) fields on symptoms, autonomic nervous system (ANS) parameters, short-term memory, and reaction time in persons with MP-related symptoms (MP participants) was investigated in a provocation study. READ MORE

5. 3. Positron Emission Tomography (PET) Studies in Anxiety Disorders

   Author : Åsa Michelgård Palmquist; Mats Fredrikson; Lars von Knorring; Hans Ågren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; amygdala; fear; anxiety; anxiety disorders; specific phobia; social phobia; posttraumatic stress disorder; PTSD; regional cerebral blood flow; rCBF; substance P; SP; neurokinin 1 receptor; NK1; GR205171; STAI-S; Psychiatry; Psykiatri; Neurobiology; Neurobiologi; Neuroscience; Neurovetenskap; Experimental brain research; Experimentell hjärnforskning; Molecular neurobiology; Molekylär neurobiologi; Radiation biology; Strålningsbiologi; Neurobiology; Neurobiologi; Neurobiology; Neurobiologi;

   Abstract : Anxiety disorders are very common and the primary feature is abnormal or inappropriate anxiety. Fear and anxiety is often mediated by the amygdala, a brain structure rich in substance P (SP) and neurokinin 1 (NK1) receptors. READ MORE

6. 4. Monoclonal antibodies to human interferon-α and interferon-γ : Characterization and application with focus on interferon-γ as a T cell cytokine

   Author : Gudrun Andersson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

   Abstract : The major functions of the immune system are to combat infections and to control that normal auto-immunity does not turn into auto-aggression. Antibodies, together with T cell receptors and MHC molecules, dictates the immunological specificity. READ MORE

7. 5. Health symptoms and potential effects on the blood-brain and blood-cerebrospinal fluid barriers associated with use of wireless telephones

   Author : Fredrik Söderqvist; Lennart Hardell; David Carpenter; Örebro universitet; []
   Keywords : radiofrequency fields; mobile telephone; DECT-telephone; cordless telephone; children; adolescents; well-being; choroid plexus; biomarkers; S100B; transthyretin; MEDICINE; MEDICIN; Medicine; Medicin;

   Abstract : Recent years have seen a rapid increase in the use of wireless telephones, yet little systematic data exist on the actual use of such devices in the general population. Mobile and cordless telephones emit radiofrequency fields (RF) raising concern about possible adverse health effects. READ MORE