Search for dissertations about: "shotgun sequencing"

Showing result 1 - 5 of 24 swedish dissertations containing the words shotgun sequencing.

  2. 1. Software Tools and Algorithms for Shotgun Sequence Assembly

    Author : Martti T. Tammi; Bruce Roe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Shotgun sequencing; multiple alignment; fragment assembly; repeats; sequencing error; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : During the last ten years, a genomics revolution has changed the ways biological research is carried out. The draft sequence of the human genome is available, as well as the sequence of 84 other completed genomes. READ MORE

  4. 2. Solving repeat problems in shotgun sequencing

    Author : Erik Arner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Shotgun sequencing; repeated DNA; genomics; whole genome shotgun; hierarchical shotgun; mate pairs; DNP; bioinformatics;

    Abstract : Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and then sheared in a random fashion. READ MORE

  5. 3. Computational methods for analysis of fragmented sequence data

    Author : Fredrik Boulund; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; metagenomics; proteomics; sequencing; distributed computing; bioinformatics;

    Abstract : Recent developments in genomic and proteomic sequencing technologies have revolutionized research in life sciences, providing new opportunities for the study of biological systems. However, modern sequence data sets are large, diverse, and heavily fragmented, which presents new challenges for their analysis and interpretation. READ MORE

  6. 4. Thermodynamics of Protein Folding and Design

    Author : Erik Sandelin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; hydrophobicity; Monte Carlo; sequence analysis; sequence assembly; shotgun sequencing; Mathematical and general theoretical physics; classical mechanics; quantum mechanics; relativity; gravitation; statistical physics; Matematisk och allmän teoretisk fysik; thermodynamics; termodynamik; Fysicumarkivet A:2000:Sandelin; statistisk fysik; relativitet; protein design; klassisk mekanik; kvantmekanik;

    Abstract : The protein folding and protein design problems are addressed, using coarse-grained models with only two types of amino acids, hydrophobic and hydrophilic. In addition to hydrophobicity forces, the models contain sequence-independent local interactions which are found to strongly influence the thermodynamics of these models. READ MORE

  7. 5. Microbial biofilm communities associated with degradation of sprayed concrete in subsea tunnels

    Author : Sabina Karacic; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; marine environment; subsea tunnels; surface structure; biofilm; steel fibers; metagenomics.; microbially induced deterioration; amplicon sequencing; concrete;

    Abstract : Deterioration of concrete leads to reduced structural strength implying high societal challenge with huge economic impact. In the Oslofjord subsea tunnel, complex microbial biofilm activity together with abiotic attack from saline groundwater are responsible for concrete matrix degradation and steel fiber corrosion. READ MORE