Search for dissertations about: "shuttle"

Showing result 16 - 20 of 59 swedish dissertations containing the word shuttle.

  2. 16. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    Author : Masoud Kazemi; Johan Åqvist; Per E. M. Siegbahn; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE

  4. 17. Behaviour and stability of shallow underground constructions

    Author : Jimmy Töyrä; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Mining and Rock Engineering; Gruv- och Berganläggningsteknik;

    Abstract : The growing needs of urbanization, like more transport possibilities, sewers, maintenance tunnels, the need of constructing shallow tunnels increase. By a better understanding of the mechanical properties and state of stress in the shallow parts of the bedrock it may be possible to determine which factors that are of importance at a specific construction site, and thereby increase the cost efficiency of pre-investigations and the tunnel construction. READ MORE

  5. 18. Control of metabolism and hormone secretion from pancreatic alpha and beta cells

    Author : Jelena Stamenkovic; Diabetes - molekylär metabolism; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLOCK genes; insulin; glucagon; metabolites; mitochondria; knock out;

    Abstract : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. READ MORE

  6. 19. Probing Catalytic Reaction Mechanisms of Biomimetic Diiron Complexes through Time-resolved Absorption Spectroscopy

    Author : Shihuai Wang; Leif Hammarström; Reiner Lomoth; Jillian Dempsey; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Artificial photosynthesis; Biomimetic catalysts; H2 formation; Catalytic intermediates;

    Abstract : Directed design of improved molecular catalysts for hydrogen evolution reactions relies on rational benchmarking based on a detailed understanding about the mechanism of catalysis. Specifically, investigation of multi-electron redox catalysis, with structural characterization of catalytic intermediates, combined with the kinetics of their transformations, can reveal the rate-limiting step of the overall reaction, possible degradation pathways and the function of structural motives. READ MORE

  7. 20. Preclinical PET imaging of Alzheimer's disease progression

    Author : Xiaotian T. Fang; Stina Syvänen; Dag Sehlin; Lars Lannfelt; Merja Haaparanta-Solin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; transgenic mice; PET; antibody-based tracer; mGluR5; ABP688; di-scFv; amyloid-β;

    Abstract : Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]PIB is a small molecule that binds only the insoluble Aβ plaque. Rather, the soluble Aβ aggregates are considered the cause of Alzheimer’s disease (AD). READ MORE