Search for dissertations about: "sib pairs"

Showing result 1 - 5 of 8 swedish dissertations containing the words sib pairs.

  2. 1. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden

    Author : Malin Engelmark; Ulf Gyllensten; Dan Holmberg; Uppsala universitet; []
    Keywords : Medicine; Cervical cancer; HPV; Affected sib-pairs; HLA; Fas; Genomewide scan; 9q32; TSCOT; Medicin;

    Abstract : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. READ MORE

  4. 2. Genetic Studies of Alzheimer's Disease

    Author : Elin Blom; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Jan Hillert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Linkage; Affected sib-pairs; APOE; APP duplication; 10q21; 19q13; Wnt signaling; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi;

    Abstract : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. READ MORE

  5. 3. Genetic studies of atopic dermatitis

    Author : Maria Bradley; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atopic dermatitis; genome-wide linkage analysis; sib pairs; candidate genes; nonparametric linkage;

    Abstract : Known from ancient times, atopic dermatitis is now the most prevalent chronic inflammatory skin disease in Swedish children. This is the result of a marked increase over the past few decades. READ MORE

  6. 4. Gene mapping of atopic dermatitis

    Author : Cilla Söderhäll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atopic dermatitis is a hereditary, pruritic, inflammatory and chronic skin disease that typically presents in early childhood. It is often associated with other atopic manifestations, such as asthma, allergic rhinoconjunctivitis, and elevated total and/or allergen-specific serum lgE levels. READ MORE

  7. 5. Diagnostic Evaluation of Schizophrenia for Genetic Studies

    Author : Birgit Ekholm; Rolf Adolfsson; Erik Jönsson; Göran Sedvall; Leif Lindström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychiatry; Schizophrenia; Diagnostic evaluation; Molecular genetic studies; Linkage; Association; Psykiatri; Psychiatry; Psykiatri; psykiatri; Psychiatry;

    Abstract : Schizophrenia is one of the most severe mental disorders. Heredity is accepted as a major causative factor. To find molecular mechanisms behind schizophrenia, patient materials with reliable and valid diagnoses must be identified. READ MORE