Search for dissertations about: "sigma-1"

Found 4 swedish dissertations containing the word sigma-1.

  2. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Author : Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Abstract : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. READ MORE

  4. 2. Endogenous and treatment-induced neuroplasticity in mouse models of Parkinson's disease

    Author : Francesco Bez; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Parkinson´s disease (PD) is an age-related neurodegenerative disorder characterized by a loss of nigral dopamine (DA) neurons that project their axons to the striatum. Striatal DA depletion causes the typical motor symptoms of PD. READ MORE

  5. 3. Neuroplasticity and neurorestoration in the treatment of Parkinson's Disease: Experimental studies in the mouse

    Author : Veronica Francardo; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. READ MORE

  6. 4. Gene Expression Changes and Brain Plasticity after Experimental Stroke

    Author : Mattias Rickhag; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; apolipoprotein D; regeneration; brain ischemia; functional recovery;

    Abstract : Stroke is the most common life-threatening neurological disease and ranks as the third leading cause of death in major industrialized countries. It is also the leading cause of serious long-term disability and about sixty percent of survivors have disabilities in their extremities. READ MORE