Search for dissertations about: "signal regulated kinase"

Showing result 1 - 5 of 121 swedish dissertations containing the words signal regulated kinase.

2. 1. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

   Author : Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Abstract : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. READ MORE

4. 2. Robustness analysis of eukaryotic signal transduction with emphasis on the HOG pathway in Saccharomyces cerevisiae

   Author : Lars-Göran Ottosson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; robustness; gTOW; signal transduction; MAPK signalling; HOG; kinase; phosphatase; transcription factor;

   Abstract : Fundamental to life, in particular for unicellular microorganisms that generally are subjected to rapidly changing environmental parameters, is the need to monitor and integrate environmental stimuli with the internal cell status. The sensing of stimuli are typically initiated at the plasma membrane and then transmitted by means of intracellular signalling networks to elicit proper cellular responses. READ MORE

5. 3. Complement receptor-mediated signal transduction in human neutrophils : A role for protein kinase C in the phagocytic process

   Author : Maria Fällman; Claes B. Wollheim; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : The neutrophil granulocyte comprises the first line of human defense against invading microorganisms. A versatile motile machinery enables the cell to migrate to the inflammatory site and there engulf and destroy the pathogens by phagocytosis. READ MORE

6. 4. Inflammatory response and intervention in experimental acute pancreatitis

   Author : Changbin Shi; Lund Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; ortopedi; traumatologi; traumatology; Surgery; orthopaedics; signalling pathways; protein kinase C; nuclear factor-kB; leukocytes; inflammatory mediators; immunosuppression; acute pancreatitis; extracellular signal-regulated kinase;

   Abstract : Acute pancreatitis (AP) is a common disease where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and remote organ dysfunction still are unclear. The overall aim of the thesis was to study mechanisms of the inflammatory response in AP with special emphasis on local, systemic, and distant organ injury directed at different signalling pathways, and potential therapeutic strategies to prevent the development of inflammation and cell injury following AP. READ MORE

7. 5. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)

   Author : Meenu Rohini Rajan; Peter Strålfors; Mats Söderström; Olga Göransson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. READ MORE