Search for dissertations about: "signaling system 7"

Showing result 1 - 5 of 174 swedish dissertations containing the words signaling system 7.

  2. 1. Exploring the tissue-specific nature of the Wnt cell signaling system : The complex world of cell communication and the search for the Achilles heel of cancer

    Author : Simon Söderholm; Claudio Cantù; Mikael Benson; Stefan Hoppler; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling; β-catenin; Development; Cancer; Stem cells; Omics; Bioinformatics;

    Abstract : The Wnt signaling pathway is a biological mechanism for cell-cell communication found across all species of the animal kingdom. This pathway plays a major role in virtually all stages of embryonic development, and it governs central aspects of stem cell biology, regeneration, and tissue homeostasis. READ MORE

  4. 2. Signaling pathways in Drosophila immunity

    Author : Shiva Seyedoleslami Esfahani; Ylva Engström; Steven Wasserman; Stockholms universitet; []
    Keywords : Drosophila immunity; signaling pathways; Cactus; NFκB; Molecular Biology; molekylärbiologi;

    Abstract : Drosophila relies on innate immunity to protect itself from its hostile environment throughout its life cycle. Despite the remarkable progress in understanding many aspects of Drosophila immunity, there are still big gaps in our knowledge. READ MORE

  5. 3. Smad signaling in hematopoietic stem cell biology

    Author : Göran Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smad7; Smad4; microarray; retroviral-mediated gene expression; conditional knockout; transforming growth factor beta; smad signaling; hematopoiesis; hematopoietic stem cells; Alk5; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. READ MORE

  6. 4. Estrogen signaling in stroke : genetic and experimental studies

    Author : Magnus Strand; Tommy Olsson; Jan Hillert; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; intracerebral hemorrhage; ischemic stroke; genetics; ERα; OPG; 17β-estradiol; enriched environment; learning and memory; hippocampus; NGFI-A; Medicine; Medicin;

    Abstract : Stroke is a common and multifactorial disease influenced by genetic and environmental risk factors. It is a highly heterogeneous entity consisting of two main types, ischemic (80%) and hemorrhagic (20%) stroke. The most common form of hemorrhagic stroke is intracerebral hemorrhage (ICH). READ MORE

  7. 5. Oncogenic ALK signaling in neuroblastoma

    Author : Ganesh Umapathy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; neuroblastoma; ERK5; Akt; MYCN; mTOR;

    Abstract : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. READ MORE