Search for dissertations about: "signalling"

Showing result 1 - 5 of 873 swedish dissertations containing the word signalling.

  1. 1. Notch signalling in carcinogenesis With special emphasis on T-cell lymphoma and colorectal cancer

    Author : Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Abstract : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. READ MORE

  2. 2. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways

    University dissertation from Stockholm : Stockholm University

    Author : Magnus J. Fredriksson; Georg Breier; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Abstract : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. READ MORE

  3. 3. Injury-Induced Signalling in Arterial Smooth Muscle Cells

    University dissertation from Sara Moses, Lund University, Dept. Cell and Molecular Biology, BMC C12, 221 84 Lund

    Author : Sara Moses; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GAG; Clinical biology; Klinisk biologi; proteoglycan; osteopontin; ERK; MAPK; signalling; smooth muscle cell; injury;

    Abstract : The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular matrix (ECM) components. It is not a static organ; the components dynamically change and reorganize in response to physiological and pathological stimuli. Vascular injury induces a complex healing process, analogous to generalised wound healing. READ MORE

  4. 4. Insulin signalling in human adipocytes mechanisms of insulin resistance in type 2 diabetes

    University dissertation from Institutionen för klinisk och experimentell medicin

    Author : Anna Danielsson; Peter Strålfors; Fredrik Nyström; Lena Stensson; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; type 2 diabetes; insulin; insulin resistance; insulin signalling; phosphorylation; insulin receptor substrate 1; feedback control; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Abstract : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. READ MORE

  5. 5. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Hooi Min Tan Grahn; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Abstract : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. READ MORE