Search for dissertations about: "signalosome"
Showing result 1 - 5 of 8 swedish dissertations containing the word signalosome.
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1. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
Abstract : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. READ MORE
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2. Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly
Abstract : AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse signal transduction pathways. READ MORE
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3. Role of coxsackie- and adenovirus receptor (CXADR/CAR) in the regulation of cell plasticity in cancer and inflammation
Abstract : The coxsackie- and adenovirus receptor (CXADR) is a transmembrane protein, which localizes at tight junctions (TJ) in epithelial cells. As highlighted by its name, CXADR was initially identified as a receptor for type C adenoviruses and group B coxsackieviruses. READ MORE
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4. A molecular network mediating adventitious root initiation in Arabidopsis thaliana
Abstract : To adapt to the ever-changing rhizosphere conditions, land plants evolved a sophisticated root system. The genetic determinants of the root system establishment have been the targets of natural selection, resulting in a very complex but robust molecular networks and circuits. READ MORE
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5. Na,K-ATPase as signaling transducer
Abstract : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. READ MORE