Search for dissertations about: "single cell gel electrophoresis assay"

Found 5 swedish dissertations containing the words single cell gel electrophoresis assay.

  1. 1. Application of Padlock Probe Based Nucleic Acid Analysis In Situ

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Henriksson; Mats Nilsson; Ulf Landegren; Harvest Gu; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Padlock probe; rolling circle amplification; single cell gel electrophoresis assay; comet assay; Crimean Congo hemorrhagic fever virus; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Abstract : The great variation displayed by nucleic acid molecules in human cells, and the continuous discovery of their impact on life, consequently require continuous refinements of molecular analysis techniques. Padlock probes and rolling circle amplification offer single nucleotide discrimination in situ, a high signal-to-noise ratio and localized detection within cells and tissues. READ MORE

  2. 2. Health of municipal sewage workers Studies of cancer incidence, biomarkers of carcinogenicity and genotoxicity, and self reported symptoms

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lennart Friis; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; Abdominal symptoms; alkaline single cell gel assay; asthma; cancer; comet assay; dyspepsia; genotoxic exposure; Helicobacter pylori; IBS; occupational epidemiology; respiratory symptoms; sewage workers; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Abstract : The occupational exposures of sewage workers are complex and variable, and include a great variety of biological and chemical agents. Previous research has focused mostly on infections and various symptoms among sewage workers, e.g. abdominal and respiratory symptoms. READ MORE

  3. 3. Measurement of primary DNA damage in individual cells from humans and mice using the alkaline single cell gel electrophoresis assay

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hamid Vaghef; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Abstract : Primary DNA damage is considered to be an important step in the development of tumours and itmay also serve as a biomarker of genotoxic stress. Measurement of DNA strand breaks in peripherallymphocytes can yield useful information about the suitability of these cells for biomonitoring purposesand subsequently risk assessment. READ MORE

  4. 4. Polyamines are involved in the regulation of S phase and DNA synthesis

    University dissertation from Department of Animal Physiology, Lund University

    Author : Kersti Alm; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Djurfysiologi; Animal physiology; cell cycle regulation; p53; DNA strand breaks; replicon organization; topoisomerase II;

    Abstract : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. READ MORE

  5. 5. DNA lesions and carcinogenicity from the urban air pollutants 2- and 3-nitrobenzanthrone

    University dissertation from Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Author : Eszter Nagy; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3-nitrobenzanthrone; 2-nitrobenzanthrone; diesel exhaust; carcinogenicity; acute toxicity; DNA adducts; oxidative stress; intratracheal; ingestion;

    Abstract : In the early 1990's, Japanese doctors in urban areas discovered an increasing incidence of lung cancer among women, which was not attributed to a change in diet or smoking. This led to a growing investigation of urban air, and subsequently the discovery of 3-nitrobenzanthrone (3-NBA), a pollutant originating from diesel emissions. READ MORE