Search for dissertations about: "single cell genomics"
Showing result 1 - 5 of 41 swedish dissertations containing the words single cell genomics.
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1. Exploring human variations by droplet barcoding
Abstract : Biological variations are being explored at ever-increasing rates through the rapid advancement of analytical techniques. Techniques like massively parallel sequencing empower scientists to accurately differentiate individuals’ genetic compositions, cellular functionalities, and healthy tissue from diseased. READ MORE
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2. Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems
Abstract : The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. READ MORE
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3. Uncovering the genetics underlying host-parasite interactions during Plasmodium falciparum malaria transmission
Abstract : In eukaryotes, cellular differentiation is often orchestrated by programmed arrays of activation and repression of genes underlying the specific phenotypes of cell-types. To complete its life cycle, the single-celled Apicomplexan parasite Plasmodium falciparum, the most deadly of the human malaria parasites, must repeatedly differentiate and convert into unique cell types that can exploit niches within their human and mosquito hosts. READ MORE
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4. Into the Single-Verse : Subtle gene expression differences between virtually identical single cells are informative of gene regulation
Abstract : The ability to profile transcriptomes and proteomes in a high-throughput fashion in single cells has truly revolutionized functional genomics, and countless functional and regulatory insights have been based on these technologies. While major applications include the discovery of new cell types and the a posteriori sorting of cell populations, studies of gene expression noise and gene co-expression have made use of this inter-cellular heterogeneity in a genuine quantitative fashion. READ MORE
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5. Variational methods for phylogeny and single-cell genomics
Abstract : The investigation of the evolutionary history of organisms, both at the cellular level and at the species level, is a relevant research topic in computational biology. These investigations lead to a deeper understanding of developmental history, cancer progression, the genetic similarity of species, and more. READ MORE