Search for dissertations about: "single molecule sensing"

Showing result 1 - 5 of 21 swedish dissertations containing the words single molecule sensing.

  2. 1. Single Molecule Detection : Microfluidic Automation and Digital Quantification

    Author : Malte Kühnemund; Mats Nilsson; Ulf Landegren; Sten Linnarsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single molecule; digital; rolling circle amplification; magnetic particle; padlock probe; microfluidics; resistive pulse sensing; lab on chip; mobile phone microscopy; enrichment; sequencing;

    Abstract : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. READ MORE

  4. 2. From single-molecule sensing to extracellular vesicles in glioma cells under stress

    Author : Virginia Claudio; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteome; single molecule sensing; nanoplasmonics; surface plasmon resonance; exosomes; glioblastoma; extracellular vesicles; cellular stress; lipid composition;

    Abstract : This thesis describes the work I conducted in two different areas, namely biomolecular sensing and quantitative cell biology. The work in the former area was focused on the optimization of plasmonic metamaterials for sensing applications, and in the latter on the characterization of extracellular vesicles released by glioblastoma cells under stress conditions. READ MORE

  5. 3. Detection and Sequencing of Amplified Single Molecules

    Author : Rongqin Ke; Mats Nilsson; Ulf Landegren; Radoje Drmanac; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; padlock probes; proximity ligation assay; rolling circle amplification; circle-to-circle amplification; single molecule detection; amplified single molecules; sequencing; in situ; single cell; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Improved analytical methods provide new opportunities for both biological research and medical applications. This thesis describes several novel molecular techniques for nucleic acid and protein analysis based on detection or sequencing of amplified single molecules (ASMs). READ MORE

  6. 4. Digital Electrical DNA Sensing

    Author : Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
    Keywords : DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

    Abstract : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. READ MORE

  7. 5. Raman and Fluorescence Spectroscopy of Single Molecules and Metal Particles

    Author : Jerk Bjerneld; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; laser-induced; single-molecule spectroscopy; surface-enhanced Raman scattering; nanoparticles;

    Abstract : Technological and conceptual advances have led to the realization of single-molecule spectroscopy. This permit detailed investigations of heterogeneous systems in fields ranging from condensed matter physics to biochemistry. It was recently discovered that surface-enhanced Raman scattering (SERS) can be used to study single molecules. READ MORE