Search for dissertations about: "single nuclear polymorphisms"

Showing result 1 - 5 of 17 swedish dissertations containing the words single nuclear polymorphisms.

2. 1. Regulation of Type I Interferon Production in Plasmacytoid Dendritic Cells : Effect of Genetic Factors and Interactions with NK Cells and B Cells

   Author : Olof Berggren; Maija-Leena Eloranta; Niels Heegaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythemtosus; IFN-alpha; autoimmunity; immune complex; single nuclear polymorphisms; Medicinsk vetenskap; Medical Science;

   Abstract : The type I interferon (IFN) system plays a central role in the etiopathogenesis of many autoimmune diseases, e.g. systemic lupus erythematosus (SLE). Activation of the type I IFN system in SLE is promoted by endogenous nucleic acid-containing immune complexes (ICs) which stimulate plasmacytoid dendritic cells (pDCs). READ MORE

4. 2. Detecting Sex and Selection in Ancient Cattle Remains Using Single Nucleotide Polymorphisms

   Author : Emma M Svensson; Anders Götherström; Juha Kantanen; Uppsala universitet; []
   Keywords : HUMANIORA; HUMANITIES; NATURVETENSKAP; NATURAL SCIENCES; aurochs; cattle; ancient DNA; SNP; pyrosequencing; selection; Bos taurus; Historical osteology; Historisk osteologi; Genetics; Genetik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : All contemporary taurine cattle originated some 10,000 years ago when their wild ancestor, the aurochs, was domesticated in the Near East. Although the aurochs was widespread also in Europe, there is no evidence for a local domestication. The aurochs has been extinct since 1627 and therefore little is known about its biology. READ MORE

5. 3. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

   Author : Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

   Abstract : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. READ MORE

6. 4. Genome Divergence in Progress - a population genetic analysis of the allopolyploid Arabidopsis suecica and its maternal parent A. thaliana

   Author : Mattias Jakobsson; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytogenetik; Genetik; cytogenetics; Genetics; sequence polymorphism; microsatellites; population structure; polyploidy; single origin; Arabidopsis thaliana; Arabidopsis suecica; genome evolution; evolutionary history; Plant genetics; Växtgenetik;

   Abstract : The evolutionary history of the allotetraploid Arabidopsis suecica and its maternal parent Arabidopsis thaliana is analyzed in the thesis in terms of genetic variation in the natural populations of the two species. The earliest phase of the speciation event in which the genomes of A. thaliana and A. READ MORE

7. 5. Genomic strategies towards the dissection of human complex disease

   Author : Tesfai Emahazion; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mapping; complex disease; polymorphism; SNP; association analysis; Alzheimer s disease; oxidative phosphorylation; apoptosis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Complex diseases are caused by the activities of many genes acting in concert with environmental factors. A major challenge facing human genetic research is to unravel the genetic factors behind complex disorders. READ MORE