Search for dissertations about: "single strand conformational polymorphism SSCP"

Showing result 1 - 5 of 6 swedish dissertations containing the words single strand conformational polymorphism SSCP.

2. 1. Search for Type 2 Diabetes Susceptibility Genes Using Multiple Approaches

   Author : Cecilia Lindgren; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single nucleotide polymorphism SNP ; transmission-disequilibrium test TDT ; genetic variation; single strand conformational polymorphism SSCP ; gene expression; insulin; glucose; genome-wide scan; linkage; genetic association; Type 2 diabetes; early onset diabetes EOD ; sekretion; diabetologi; Endokrinologi; diabetology; Endocrinology; secreting systems; signal-to-noise ratio SNR ;

   Abstract : Type 2 diabetes mellitus is a multifactorial disorder characterized by chronic hyperglycemia resulting from pancreatic dysfunction and insulin resistance. It is a common disorder with a complex pattern of inheritance, likely to reflect the influence of multiple genetic and environmental factors on the diabetes risk. READ MORE

4. 2. Molecular biological techniques as a tool in diagnostic pathology : Applications in B-cell lymphoproliferative disease, medullary thyroid carcinoma and cervical carcinoma

   Author : Mansour Alemi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; PCR-SSCP; MTC; RET mutation; Lymphoma; HPV; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : Identification of malignancy associated with mutations in gene sequences requires detection ofas little as a single base difference. A powerful technique in mutation detection is polymerasechain reaction (PCR) followed by single-strand conformational polymorphism (SSCP) andsequencing. READ MORE

5. 3. Studies on basal cell carcinoma with emphasis on the role of the human homologue of the Drosophila patched gene

   Author : Anne Birgitte Undén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Basal cell carcinoma BCC ; carcinogenesis; in situ hybridization; linkageanalysis; gene; mutation; PCR; p53; PTCH; SHH; skin; SSCP; stromelysin 3 ST3 ; trichoepithelioma TE ; UVR.;

   Abstract : Basal cell cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. Ultraviolet radiation (WR) is presumed to be the predominant environmental factor. READ MORE

6. 4. Alterations of the short arm of chromosome 9p in lymphoid malignancies

   Author : Mats Heyman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malignant disease evolves through the successive accumulation of genetic lesions affecting growth-controlling genes in the cell-clone undergoing malignant transformation. 9p21 has long been suspected to harbour a tumour suppressor gene, because of frequent deletions of this region in malignancies including acute lymphocytic leukaemia (ALL). READ MORE

7. 5. Molecular studies in breast cancer susceptibility genes

   Author : Jindong Chen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : familial breast cancer; breast cancer susceptibility gene; BRCA1; BRCA2; ATM; TP53; PTEN MMAC1; STK11 LKB1; gene mutation; mutation screening; LOH;

   Abstract : Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. READ MORE