Search for dissertations about: "single-stranded oligonucleotide ssON"

Found 3 swedish dissertations containing the words single-stranded oligonucleotide ssON.

  2. 1. The role of non-coding single-stranded oligonucleotides on Respiratory syncytial virus infection

    Author : Sandra Axberg Pålsson; Anna-Lena Spetz; Annika Karlsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Respiratory syncytial virus RSV ; single-stranded oligonucleotide ssON ; small non-coding RNA sncRNA ; nucleolin; virus infection; antiviral; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Respiratory syncytial virus (RSV) is an enveloped RNA virus of the Pneumoviridae family. RSV is reported to infect host cells by receptor-mediated endocytosis, also called clathrin-dependent endocytosis. Many reports indicate that the virus utilizes the host receptor nucleolin for entry. READ MORE

  4. 2. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity

    Author : Aleksandra Dondalska; Anna-Lena Spetz; Jenny Hallgren Martinsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; single-stranded oligonucleotides; Toll-like receptors; influenza; respiratory syncytial virus; dendritic cell; mast cell; virus infection; inflammation; itch; molekylär biovetenskap; Molecular Bioscience;

    Abstract : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. READ MORE

  5. 3. Peripheral Regulation of Pain and Itch

    Author : Elín Ingibjörg Magnúsdóttir; Malin C. Lagerström; George H. Caughey; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; itch; CGRP; TRPV1; mast cell; mast cell protease; mMCP4; mMCP6; CPA3; endothelin-1; compound 48 80; MRGPRX2; single-stranded oligonucleotide;

    Abstract : Pain and itch are diverse sensory modalities, transmitted by the somatosensory nervous system. Stimuli such as heat, cold, mechanical pain and itch can be transmitted by different neuronal populations, which show considerable overlap with regards to sensory activation. READ MORE