Search for dissertations about: "skin disease"
Showing result 21 - 25 of 419 swedish dissertations containing the words skin disease.
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21. Disease-causing Keratin Mutations and Cytoskeletal Dysfunction in Human Skin : In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses
Abstract : Epidermolysis bullosa simplex (EBS) and epidermolytic ichthyosis (EI) are rare skin fragility diseases characterized by intra-epidermal blistering due to autosomal dominant-negative mutations in basal (KRT5 or KRT14) and suprabasal (KRT1 or KRT10) keratin genes, respectively. Despite vast knowledge in the disease pathogenesis, the pathomechanisms are not fully understood, and no effective remedies exist. READ MORE
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22. Transforming growth factor-ß. Signal regulation in health and disease
Abstract : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. READ MORE
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23. Aspects on Chronic Venous Disease of the Lower Limb
Abstract : Controversies exist regarding both what is required for a proper diagnosis of chronic venous disease (CVD), and what treatment to offer patients. An objective evaluation is mandatory to individualize treatment. READ MORE
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24. Biophysical aspects of the skin barrier : towards increased non-invasive extraction and optimized biomarker sampling
Abstract : The skin provides a link to the body’s health via its rich variety of high and low molecular weight biomarkers, reflecting both systemic diseases (e.g., cancer, diabetes) and local skin disorders (e.g. READ MORE
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25. Composition and maintenance of skin resident T-cells in health and disease
Abstract : Tissue-resident memory T cells (TRM) reside in healthy skin at sites of previous infections. Upon re-infection, TRM cells rapidly respond by initiating tissue inflammation and exert effector functions to eliminate pathogens. TRM cells are potent effector cells and as such, they are key players in focal inflammatory skin diseases. READ MORE