Search for dissertations about: "sle disease"

Showing result 1 - 5 of 132 swedish dissertations containing the words sle disease.

2. 1. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity

   Author : Kristina Juneblad; Gerd-Marie Alenius; Solbritt Rantapää-Dahlqvist; Lars-Erik Kristenssen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriatic Arthritis; genetics; inflammasomes; polymorphisms; biomarkers; disease expression; disease activity; cardiovascular diseases; mortality; epidemiology;

   Abstract : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. READ MORE

4. 2. Osteoporosis in SLE

   Author : Katarina Almehed; Göteborgs universitet; []
   Keywords : osteoporosis; systemic lupus erythematosus; bone mineral density; health-related quality of life; SF-36; resistin; cross sectional study; vertebral fracture;

   Abstract : As the treatment of Systemic Lupus Erythematosus (SLE) has become more effective the focus has partly shifted from main concern of short term morbidity and survival to long term complications such as osteoporosis. The aims of this thesis were to a) determine prevalence and risk factors of osteoporosis and of b) vertebral fractures c) evaluate if adequate osteoporotic treatment was provided d) determine if resistin, an adipokine with proposed pro-inflammatory properties, was associated with markers of inflammation or bone mineral density (BMD) and to e) investigate patients self reported health related quality of life (HRQOL) and its relationship to disease variables and employment status in female SLE patients. READ MORE

5. 3. Studies on Cardiovascular Disease in Systemic Lupus Erythematosus

   Author : Helena Tydén; Reumatologi och molekylär skelettbiologi; []
   Keywords : SLE glomerulonephritis; endothelial activation; type I interferon; S100 Proteins; Cardiovascular Disease;

   Abstract : .... READ MORE

6. 4. On the etiology and pathogenesis of systemic lupus erythematosus with special reference to environmental factors

   Author : Anders Bengtsson; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; Risk factors; Human parvovirus B19; Immune complex; Disease activity; Interferon-alpha; SLE; Retrovirus;

   Abstract : Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which environmental factors interact with genetic factors in the development of the disease process and evolution of clinical manifestations. In this thesis both exogenous factors and host factors were investigated, as well as important immunopathological aspects including involvement of immune complex (IC), the complement system and interferon-alpha (IFN-α). READ MORE

7. 5. The activation and regulation of plasmacytoid dendritic cells in SLE : and possible therapeutic interventions

   Author : Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

   Abstract : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. READ MORE