Search for dissertations about: "sle thesis"

Showing result 1 - 5 of 144 swedish dissertations containing the words sle thesis.

  1. 1. Osteoporosis in SLE

    Author : Katarina Almehed; Göteborgs universitet.; Gothenburg University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; systemic lupus erythematosus; bone mineral density; health-related quality of life; SF-36; resistin; cross sectional study; vertebral fracture;

    Abstract : As the treatment of Systemic Lupus Erythematosus (SLE) has become more effective the focus has partly shifted from main concern of short term morbidity and survival to long term complications such as osteoporosis. The aims of this thesis were to a) determine prevalence and risk factors of osteoporosis and of b) vertebral fractures c) evaluate if adequate osteoporotic treatment was provided d) determine if resistin, an adipokine with proposed pro-inflammatory properties, was associated with markers of inflammation or bone mineral density (BMD) and to e) investigate patients self reported health related quality of life (HRQOL) and its relationship to disease variables and employment status in female SLE patients. READ MORE

  2. 2. The activation and regulation of plasmacytoid dendritic cells in SLE and possible therapeutic interventions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

    Abstract : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. READ MORE

  3. 3. On the etiology and pathogenesis of systemic lupus erythematosus with special reference to environmental factors

    University dissertation from Anders Bengtsson, Dept of Rheumatology, University Hospital, S-221 85 Lund, Sweden

    Author : Anders Bengtsson; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; Risk factors; Human parvovirus B19; Immune complex; Disease activity; Interferon-alpha; SLE; Retrovirus;

    Abstract : Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which environmental factors interact with genetic factors in the development of the disease process and evolution of clinical manifestations. In this thesis both exogenous factors and host factors were investigated, as well as important immunopathological aspects including involvement of immune complex (IC), the complement system and interferon-alpha (IFN-α). READ MORE

  4. 4. Systemic Lupus Erythematosus, with focus on vascular wall changes, cardiac risk-factor awareness and cardiovascular events

    University dissertation from Section of Rheumatology

    Author : Christine Bengtsson; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvascular reactivity; arteria stiffness; cardiac risk factors; Cardiovascular event; SLE;

    Abstract : Systemic Lupus Erythematosus is an autoimmune disease with a wide range of disease manifestations with respect to severity and magnitude of organ involvement. An increased risk of cardiovascular disease (CVD) compared with the general population causes both morbidity and mortality in SLE patients. READ MORE

  5. 5. The PD-1 pathway and the complement system in systemic lupus erythematosus

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Helga Kristjánsdóttir; Marta E Alarcón-Riquelme; Kristján Steinsson; Tom W J Huizinga; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SLE; autoimmune diseases; PD-1; C4AQ0; low MBL; multicase family; NATURAL SCIENCES Biology Cell and molecular biology Immunology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi; medicinsk genetik; Medical Genetics;

    Abstract : Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. READ MORE