Search for dissertations about: "sle virus"

Showing result 1 - 5 of 13 swedish dissertations containing the words sle virus.

2. 1. On the etiology and pathogenesis of systemic lupus erythematosus with special reference to environmental factors

   Author : Anders Bengtsson; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; Risk factors; Human parvovirus B19; Immune complex; Disease activity; Interferon-alpha; SLE; Retrovirus;

   Abstract : Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which environmental factors interact with genetic factors in the development of the disease process and evolution of clinical manifestations. In this thesis both exogenous factors and host factors were investigated, as well as important immunopathological aspects including involvement of immune complex (IC), the complement system and interferon-alpha (IFN-α). READ MORE

4. 2. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

   Author : Kristina Nyström; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

   Abstract : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. READ MORE

5. 3. Neuroimmunological and clinical studies in neuropsychiatric lupus erythematosus (NPSLE)

   Author : Liisa Hopia; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with many organ manifestations and characteristic immunological abnormities including a large set of autoantibodies with affinity for nuclear and membrane components. Autoantibodies form immune complexes, which cause inflammation and tissue damage in affected organs. READ MORE

6. 4. A study on the E3 ligase TRIM21/Ro52

   Author : Alexander Espinosa; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 autoantibodies is used as a diagnostic tool, the biological function of TRIM21/Ro52 is still unknown. READ MORE

7. 5. Immune responses to the Ro and La autoantigens

   Author : Pia Tengnér; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Sjögren s syndrome; systemic lupus erythematosus; Ro SS-A; La SS-B;

   Abstract : Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are rheumatic diseases characterized by autoantibody production directed to the Ro/SS-A and La/SS-B autoantigens. The Ro/SS-A is a complex of one of four small RNAs denoted hY RNAs, and three proteins; Ro 60kD, Ro 52kD and La. READ MORE