Search for dissertations about: "small RNAs"

Showing result 16 - 20 of 103 swedish dissertations containing the words small RNAs.

  2. 16. Structure, function and metabolic stability of antisense RNAs

    Author : Fredrik Söderbom; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Mikrobiologi; Microbiology; Mikrobiologi; mikrobiologi; Microbiology;

    Abstract : Antisense RNAs usually are small, highly structured, unstable RNAs that control a varietyof different biological processes. They exert their effect by binding to complementarytarget RNAs and thereby inhibit their functions. READ MORE

  4. 17. Small non-coding RNA in early fly development : plasticity, interactions and improved bioinformatic tools

    Author : Lovisa Örkenby; Anita Öst; Rashmi Ramesh; Daniel Nätt; Nicola Iovino; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Maternal-to-zygotic transition; sncRNA; miRNA; piRNA; Embryogenesis; Zygotic gene activation;

    Abstract : At fertilization, the male and female pronuclei undergo a transformation from germline to pluripotency as they fuse, marking the beginning of Drosophila embryogenesis. As the parental contributions decrease, the zygote takes control of its genome in a process called the maternal-to-zygotic transition (MZT). READ MORE

  5. 18. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    Author : Hanna Hedman; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Abstract : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. READ MORE

  6. 19. Evolutionary consequences of dominance at the Brassicaceae self-incompatibility locus

    Author : Jörg Alexander Bachmann; Tanja Slotte; Vincent Castric; Ove Eriksson; Pär Ingvarsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Capsella; mating system shift; self-fertilization; self-incompatibility; small RNA; dominance; Arabidopsis; population genetics; genomics; gene expression; ekologi och evolution; Ecology and Evolution;

    Abstract : Self-incompatibility (SI) is a genetic mechanism that allows plants to enforce outcrossing by rejecting self-pollen and pollen from close relatives. In the Brassicaceae, SI is sporophytic and controlled by the self-incompatibility locus (S-locus). READ MORE

  7. 20. Potential therapies and biomarkers for LAMA2-CMD. Does the microRNA hype deliver?

    Author : Bernardo Moreira Soares Oliveira; Muskelbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskeldystrofi; genetic-markers; Small non-coding RNAs;

    Abstract : Laminin α2 chain-deficient muscular dystrophy, or LAMA2-CMD, is a very severe disease caused by mutations in the LAMA2 gene. Skeletal muscle is the most affected tissue, with patients presenting symptoms such as hypotonia at birth, joint contractures and progressive muscle wasting. READ MORE