Search for dissertations about: "sodium channels"

Showing result 1 - 5 of 35 swedish dissertations containing the words sodium channels.

  2. 1. The interplay of ions in the stimulation of the pancreatic -cell

    Author : Michael Eberhardson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pancreatic β-cells; cytoplasmic calcium; oscillations; glucose; tetrodotoxin; tolbutamide; veratridine; tetraethylammonium; quinine; cesium; H2DIDS; furosemide; transients; microfluorometry; fura-2; MQAE; calcium channels; potassium channels; sodium channels; chloride channels; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Glucose stimulation of insulin release is mediated by depolarisation of the pancreatic β-cells with accompanying entry of Ca2+ through voltage-dependent channels. An important feature of the glucose-induced depolarisation is its rhythmicity causing oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), which trigger pulsatile release of insulin. READ MORE

  4. 2. Gating and modulation mechanism of voltage gated sodium channels

    Author : Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

    Abstract : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. READ MORE

  5. 3. Tetrodotoxin-resistant sodium channels in neuropathic pain

    Author : Jenny Fjell Hjelmström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : spinal sensory neurons; nociceptor; IB4; tetrodotoxin; sodium channels; SNS PN3; NaN SNS2; gene regulation; NGF; GDNF; in situ hybridization; immunofluorescence; sodium currents; neuropathic pain models; Taiep;

    Abstract : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. READ MORE

  6. 4. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease

    Author : Michelle Nilsson; Antonios Pantazis; Fredrik Elinder; Henry M. Colecraft; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. READ MORE

  7. 5. Role of potassium channels in regulating neuronal activity

    Author : Göran Klement; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

    Abstract : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. READ MORE