Search for dissertations about: "sodium currents"

Showing result 1 - 5 of 11 swedish dissertations containing the words sodium currents.

  2. 1. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

    Author : Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

    Abstract : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. READ MORE

  4. 2. Tetrodotoxin-resistant sodium channels in neuropathic pain

    Author : Jenny Fjell Hjelmström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : spinal sensory neurons; nociceptor; IB4; tetrodotoxin; sodium channels; SNS PN3; NaN SNS2; gene regulation; NGF; GDNF; in situ hybridization; immunofluorescence; sodium currents; neuropathic pain models; Taiep;

    Abstract : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. READ MORE

  5. 3. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

    Author : Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

    Abstract : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. READ MORE

  6. 4. Mechanism of Action of the Antiarrhythmic Agent AZD7009

    Author : Frida Persson; Göteborgs universitet; []
    Keywords : atrial fibrillation; antiarrhythmic drug; IKr; IKur; Ito; IKs; IKACh; INa; ICaL; cardiac action potential; early afterdepolarisation;

    Abstract : Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration (APD) and the refractory period. READ MORE

  7. 5. Lightweight multifunctional composites : An investigation into ion-inserted carbon fibres for structural energy storage, shape-morphing, energy harvesting & strain-sensing

    Author : Ross Harnden; Dan Zenkert; Paolo Ermanni; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Flyg- och rymdteknik; Aerospace Engineering;

    Abstract : The transport sector accounts for around 26% of all greenhouse gas emissions in the European Union and United Kingdom. By reducing the mass of vehicles it is possible to reduce these emissions substantially.One way to reduce vehicle mass is to use multifunctional structures. READ MORE