Search for dissertations about: "solid dispersions"
Showing result 1 - 5 of 28 swedish dissertations containing the words solid dispersions.
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1. Multiscale X-ray Characterisation of Cellulose-based Solid Dispersions
Abstract : Cellulose-based solid dispersions are a promising formulation strategy for providing controlled drug release and dissolution enhancement of poorly soluble drugs. These dispersions can from structures on multiple length scales which can have both positive and negative effects on the functional properties of the formulation. READ MORE
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2. PEG and lipids in solid dispersions and liquid crystals - structure and phase behaviour
Abstract : In this thesis, two different kinds of nano-structured systems have been studied; solid dispersion systems of polyethylene glycol (PEG) and liquid crystalline systems containing the polar lipids monoolein (MO) and phytantriol (PT). Solid dispersions of PEG were studied with addition of different substances, lipids or parabens. READ MORE
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3. Film Formation from Dispersions - Preparation and Mechanisms
Abstract : Improved environmental consciousness and harsh legislation concerning volatile organic compounds (VOCs) during the 1980s led to an increase in the development in the field of polymer colloids. Solvent born coatings were replaced by polymer dispersions in aqueous solution, so called latex dispersions. READ MORE
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4. Drugs and polymers in dissolving solid dispersions : NMR imaging and spectroscopy
Abstract : The number of poorly water-soluble drug substances in the pharmaceutical pipeline is increasing, and thereby also the need to design effective drug delivery systems providing high bioavailability. One favourable formulation approach is preparation of solid dispersions, where dispersing a poorly water-soluble drug in a water-soluble polymer matrix improves the dissolution behaviour and the bioavailability of the drug. READ MORE
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5. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs
Abstract : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. READ MORE