Search for dissertations about: "solid dissolution"

Showing result 1 - 5 of 95 swedish dissertations containing the words solid dissolution.

  2. 1. Experimental studies of radiation-induced dissolution of UO2 : The effect of intrinsic solid phase properties and external factors

    Author : Alexandre Barreiro Fidalgo; Mats Jonsson; David Shoesmith; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidation; dissolution; uranium dioxide; gadolinium; bentonite; sulfide; hydrogen; gamma radiation; radiolysis; hydrogen peroxide; hydroxyl radical; repository; Kemi; Chemistry;

    Abstract : Dissolution of the UO2 matrix is one of the potential routes for radionuclide release in a future deep geological repository for spent nuclear fuel. This doctoral thesis focuses on interfacial reactions of relevance in radiation-induced dissolution of UO2 and is divided in two parts:In the first part, we sought to explore the effects of solid phase composition:The impact of surface stoichiometry on the reactivity of UO2 towards aqueous radiolytic oxidants was studied. READ MORE

  4. 2. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

    Author : Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. READ MORE

  5. 3. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

    Author : Amjad Alhalaweh; Peter York; Luleå tekniska universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; crystal engineering; cocrystal; formation; solubility; pH; dissolution; surface properties; solid-state properties; Health Science; Hälsovetenskap;

    Abstract : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. READ MORE

  6. 4. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

    Author : Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
    Keywords : Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. READ MORE

  7. 5. Physical and Chemical Aspects of Radiation Induced Oxidative Dissolution of UO2

    Author : Olivia Roth; Mats Jonsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; UO2; spent nuclear fuel; dissolution; oxidation; radiolysis; irradiation; particle size; modeling; Chemistry; Kemi;

    Abstract : Denna licensiatavhandling behandlar oxidativ upplösning av UO2. Upplösning av UO2 studeras huvudsakligen då UO2-matrisen hos använt kärnbränsle förväntas fungera som en barriär mot frigörande av radionuklider i ett framtida djupförvar. READ MORE