Search for dissertations about: "solid-phase synthesis"

Showing result 1 - 5 of 82 swedish dissertations containing the words solid-phase synthesis.

  2. 1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy

    Author : Mickael Mogemark; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; Organic chemistry; Organisk kemi;

    Abstract : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. READ MORE

  4. 2. Methodological studies in solid phase synthesis : Linkers and applications of multi-component condensations

    Author : Mikael Erlandsson; Anders Undén; Thomas Norberg; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid phase peptide synthesis; solid phase organic chemistry; linkers; self-scavenging; safety catch linker; cyclic peptides; reductive acidolysis; disulfides; reduction; metallic zinc; multi-component condensations; combinatorial chemistry; Neurochemistry; Neurokemi;

    Abstract : Solid phase synthesis has become an increasingly important tool in the synthesis of oligopolymers and small organic molecules. This thesis covers three important areas in the solid phase synthesis technique: linker strategies, reduction methods and novel routes to complex heterocycles. READ MORE

  5. 3. Glycoconjugates : Solid-phase synthesis and biological applications

    Author : Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

    Abstract : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. READ MORE

  6. 4. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

    Author : Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

    Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE

  7. 5. Iron Carbonyl Mediated Parallel Synthesis

    Author : Henrik Gradén; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dienyl; scavenger; solid phase; galectin inhibitor; oseltamivir; iron carbonyl complex; polymer bound reagent; cation; linker; parallel synthesis; active ester;

    Abstract : This thesis describes the examination and development of cationic iron carbonyl complexes for use in parallel synthesis both in solution phase and on solid phase. A solution phase methodology for carbon-carbon and carbon-heteroatom formation, utilizing polymer bound reagents and scavengers and amenable for automation has been successfully developed. READ MORE