Search for dissertations about: "solid-phase synthesis"

Showing result 1 - 5 of 85 swedish dissertations containing the words solid-phase synthesis.

  1. 1. Solid-phase glycoconjugate synthesis on-resin analysis with gel-phase ¹9F NMR spectroscopy

    University dissertation from Umeå : Kemi

    Author : Mickael Mogemark; Umeå universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. READ MORE

  2. 2. Methodological studies in solid phase synthesis : Linkers and applications of multi-component condensations

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Mikael Erlandsson; Stockholms universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid phase peptide synthesis; solid phase organic chemistry; linkers; self-scavenging; safety catch linker; cyclic peptides; reductive acidolysis; disulfides; reduction; metallic zinc; multi-component condensations; combinatorial chemistry; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi;

    Abstract : Solid phase synthesis has become an increasingly important tool in the synthesis of oligopolymers and small organic molecules. This thesis covers three important areas in the solid phase synthesis technique: linker strategies, reduction methods and novel routes to complex heterocycles. READ MORE

  3. 3. Glycoconjugates Solid-phase synthesis and biological applications

    University dissertation from Umeå : Kemi

    Author : Fredrik Wallner; Umeå universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. READ MORE

  4. 4. Antigens derived from the mucin MUC1 Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

    University dissertation from Umeå : Kemi

    Author : Maciej Pudelko; Umeå universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE

  5. 5. Combinatorial Synthesis of Pilicides

    University dissertation from Anette Svensson, Organic Chemistry 2, Chemical Center, Lund University

    Author : Anette Svensson; Lund University.; Lunds universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gel-phase 19F NMR spectroscopy; fluorinated linkers; E. coli bacteria; pilicides; combinatorial chemistry; solid-phase synthesis; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i. READ MORE