Search for dissertations about: "solid-phase synthesis"

Showing result 11 - 15 of 82 swedish dissertations containing the words solid-phase synthesis.

  2. 11. Design and synthesis of steroid mimetic libraries using solid phase techniques

    Author : Marcus Ruda; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pyridone; quinolone; benzoindazole; solid phase chemistry; scavenger resin; combinatorial chemistry; alpha-arylation; nuclear hormone receptor; steroid mimetic.;

    Abstract : This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure was designed mimicking the ABC-rings of a steroid. READ MORE

  4. 12. Some contributions to the methodology of solid phase peptide synthesis

    Author : Ulf Ragnarsson; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  5. 13. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

    Author : Hans Emtenäs; Ulf Nilsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE

  6. 14. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Author : Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Abstract : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. READ MORE

  7. 15. Further development of light-up probes : dye synthesis and PCR applications

    Author : Jennie Isacsson; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; asymmetric cyanine dyes; homogeneous assays; flourecent hybridisation probes; light-up probes; peptide nucleic acids; PCS; solid phase synthesis; LightUp probe;

    Abstract : .... READ MORE