Search for dissertations about: "solid-phase synthesis"
Showing result 21 - 25 of 82 swedish dissertations containing the words solid-phase synthesis.
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21. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors
Abstract : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. READ MORE
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22. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library
Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE
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23. Chemical Engineering of Small Affinity Proteins
Abstract : Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. READ MORE
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24. Strategies for developing peptide and protein selective plastic antibodies
Abstract : The objective of the thesis was to explore approaches for the development of molecularly imprinted materials with predetermined selectivity for peptide or protein targets. In particular, the work has focused on molecularly imprinted nanoparticles synthesized using solid-phase synthesis protocols. READ MORE
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25. Functional Copolymers of Polyvinylpyrrolidone
Abstract : In many ways, polyvinylpyrrolidone (PVP) has a unique combination of chemical and physical properties. Unlike most polymers it is soluble in water as well as a number of organic solvents. PVP also has excellent film forming properties, outstanding chemical stability, complexing ability, low toxicity, and good adherence to many different substrates. READ MORE