Search for dissertations about: "solubility drug"
Showing result 1 - 5 of 58 swedish dissertations containing the words solubility drug.
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1. Computational Analysis of Aqueous Drug Solubility – Influence of the Solid State
Abstract : Aqueous solubility is a key parameter influencing the bioavailability of drugs and drug candidates. In this thesis computational models for the prediction of aqueous drug solubility were explored. READ MORE
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2. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption
Abstract : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. READ MORE
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3. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo
Abstract : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. READ MORE
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4. Microscopic views of drug solubility
Abstract : The development of computational models for predicting drug solubility has increased drastically during the last decades. Nevertheless these models still have diffculties to estimate the aqueous solubility as accurate as desired. READ MORE
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5. Microscopic Interpretations of Drug Solubility
Abstract : .... READ MORE