Search for dissertations about: "solubility parameter"

Showing result 1 - 5 of 17 swedish dissertations containing the words solubility parameter.

  1. 1. Computational Analysis of Aqueous Drug Solubility – Influence of the Solid State

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Carola Wassvik; Uppsala universitet.; [2006]
    Keywords : Pharmaceutics; intrinsic solubility; solubility prediction; drug solubility; solid state; melting point; enthalpy of melting; entropy of melting; solvation; free energy of hydration; QSPR; multivariate analysis; PCA; PLS; Galenisk farmaci;

    Abstract : Aqueous solubility is a key parameter influencing the bioavailability of drugs and drug candidates. In this thesis computational models for the prediction of aqueous drug solubility were explored. READ MORE

  2. 2. Model for activity coefficients and solubilities of Na2CO3 and Na2SO4 in high-temperature solutions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marta Anna Bialik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; scaling; Pitzer model; activity coefficient; solubility; sodium carbonate; sodium sulfate; boiling point raise; double salt; solid solution; burkeite;

    Abstract : Scaling of sodium sulfate and sodium carbonate double salts has long been recognized as a problem in the black liquor evaporation process. These salts are abundant in black liquor and often tend to precipitate on heat transfer areas, thereby significantly decreasing the heat transfer efficiency. READ MORE

  3. 3. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Eva Persson; Uppsala universitet.; [2006]
    Keywords : Biopharmacy; solubility; drug dissolution; food effects; poorly soluble drugs; P-gp inhibition; drug absorption; pemeability; bile acids; phospholipids; human intestinal fluid; simulated intestinal fluid; neutral lipids; solid phase extraction; HPLC; Efflux; Biofarmaci;

    Abstract : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. READ MORE

  4. 4. Methodology for high-throughput production of soluble recombinant proteins in Escherichia coli

    University dissertation from Stockholm : KTH

    Author : Katrin Markland; Gen Larsson; Pär Nordlund; Jenny Ottosson; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; high-throughput methodology; recombinant protein production; solubility; productivity; quality; cultivation technology; parallel reactors; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : The aim of this work was to investigate and determine central parameters that can be used to control and increase the solubility, quality and productivity of recombinant proteins. These central parameters should be applicable under the constraints of high-throughput protein production in Escherichia coli. READ MORE

  5. 5. Thermodynamic Modelling of Electrolyte Solutions with Application to the Pulp and Paper Industry

    University dissertation from Chemical Engineering, Lund University

    Author : Anders Jaretun; [2000]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Potassium; Chloride; Chemical recovery; Leaching; Crystallization; Kraft pulping; Non-process elements; Solubility; Local composition; Excess properties; Osmotic coefficient; Electrolytes; Activity coefficient; Wood; pulp and paper technology; Pappers- och massateknik;

    Abstract : A thermodynamic model for electrolyte solutions has been derived for binary and multicomponent solutions up to very high molalities. The model was extensively tested on 163 binary aqueous electrolyte systems up to very high molalities, and the results show that the model represents mean ionic activity coefficients and osmotic coefficients very accurately. READ MORE