Search for dissertations about: "solubility prediction"
Showing result 6 - 10 of 25 swedish dissertations containing the words solubility prediction.
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6. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo
Abstract : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. READ MORE
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7. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs
Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE
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8. Removal processes in sewage treatment plants : Sludge quality and treatment efficiency of structurally diverse organic compounds
Abstract : Large and ever-increasing numbers of chemicals, including large quantities of a broad spectrum of organic compounds are used in modern society. More than 30 000 of the more than 100 000 chemical substances registered in the EU are estimated to be daily used, of which many will be discharged into the waste-streams handled by municipal sewage treatment plants (STPs). READ MORE
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9. Polymeric materials in nuclear power plants : Lifetime prediction, condition monitoring and simulation of ageing
Abstract : Nuclear power plants generate a significant part of the world’s electrical power consumption. However, many plants are nearing the end of their designed lifetime, and to extend the lifetime it is important to verify that every component can withstand the added service time. This includes polymeric materials, which become brittle with time. READ MORE
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10. Computational models for the prediction of intestinal membrane permeability
Abstract : Lead compounds generated in high-throughput drug discovery programs often have unfavorable biopharmaceutical properties, resulting in a low success rate for such drug candidates in clinical development. Efficient and reliable methods that predict biopharmaceutical properties, such as intestinal permeability and solubility are therefore required in order to reduce the attrition rate during development of these compounds. READ MORE
