Search for dissertations about: "soluble TNF receptor"

Showing result 1 - 5 of 52 swedish dissertations containing the words soluble TNF receptor.

  2. 1. Processing of TNF-receptors to soluble receptor forms in myeloid cells

    Author : Flemming Björnberg; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation cytokine TNF receptor; extracellular fluids; Haematology; Hematologi; extracellulära vätskor;

    Abstract : TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. READ MORE

  4. 2. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Author : Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Abstract : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. READ MORE

  5. 3. TNF-α and neurotrophins in Achilles tendinosis

    Author : Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Abstract : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. READ MORE

  6. 4. Leukocyte receptor alternations during systemic inflammatory responses

    Author : Olof Ljunghusen; Per Venge; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The leukocyte adhesion molecule CD llb is very important when granulocytes and monocytes leave the blood stream. This adhesion molecule is stored preformed intracellularly, and can upon stimulation of the cells by, for example, complement split products, be mobilized to the cell surface. READ MORE

  7. 5. Cytokines and their soluble receptors in nasal fluids from school children with allergic rhinitis

    Author : Mikael Benson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergic rhinitis; school children; cytokines; soluble cytokine receptors; nasal fluids;

    Abstract : Allergic inflammation is associated with a shift in the balance between cytokines produced by two T helper subsets (Th1 and Th2) towards a preponderance of Th2 cells. Interleukin (IL)-4 is produced by Th2 cells and interferon-g (IFN-g) by Th1 cells. The ratio IL-4/IFN-g is often used as a marker of the balance between the cytokines. READ MORE