Search for dissertations about: "soluble solid"

Showing result 1 - 5 of 101 swedish dissertations containing the words soluble solid.

  2. 1. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

    Author : Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
    Keywords : Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. READ MORE

  4. 2. Study of bio-oil and bio-char production from thermal and catalytic hydrotreatment of simulated pyrolysis oil under mild conditions

    Author : Elham Nejadmoghadam; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Stabilization; soluble solid; alumina-supported catalyst; insoluble solid char; simulated pyrolysis oil; catalytic hydrotreatment;

    Abstract : Pyrolysis oil derived from fast pyrolysis of lignocellulosic biomass is a promising alternative energy source used to produce renewable biofuels. However, the high reactivity of unsaturated oxygenated compounds in pyrolysis oil results in charring and deactivation of the catalyst under severe hydrotreatment conditions. READ MORE

  5. 3. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

    Author : Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE

  6. 4. Multiscale X-ray Characterisation of Cellulose-based Solid Dispersions

    Author : Martina Olsson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PXCT; WAXS; pharmaceutical formulations; multiscale characterisation; STXM; radiation damage; SAXS; X-ray imaging; solid dispersions; cellulose;

    Abstract : Cellulose-based solid dispersions are a promising formulation strategy for providing controlled drug release and dissolution enhancement of poorly soluble drugs. These dispersions can from structures on multiple length scales which can have both positive and negative effects on the functional properties of the formulation. READ MORE

  7. 5. 3D printing of lipid-based formulations into personalized solid oral dosage forms

    Author : Jenny Johannesson; Christel Bergström; Alexandra Teleki; Mattias Paulsson; Maria Strömme; Abdul Basit; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; poorly water-soluble drug; lipid-based formulation; Pickering emulsion; emulsion gel; semi-solid extrusion; 3D printing; lipid tablet; personalized dosage form; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all. This is problematic, especially for patient populations with high patient-to-patient variability, as in pediatrics. READ MORE