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Showing result 1 - 5 of 532 swedish dissertations matching the above criteria.

2. 1. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

   Author : Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Abstract : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. READ MORE

4. 2. Prognostic and Predictive Somatic Mutations in Colorectal Cancer

   Author : Luís Nunes; Tobias Sjöblom; Bengt Glimelius; Snehangshu Kundu; Ivaylo Stoimenov; Laura DeLong Wood; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; somatic mutations; next-generation sequencing; whole-genome sequencing; transcriptomics; targeted therapy; prognosis; Medicinsk vetenskap; Medical Science;

   Abstract : Colorectal cancer (CRC) is the third most incident and the second deadliest cancer worldwide. Even though CRC incidence is strongly correlated with age, it has been increasing in developing countries and younger individuals. READ MORE

5. 3. Somatic Genetic Variation in Children: from Mosaicism to Cancer

   Author : Anders Valind; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic Mosaicism; Cancer; Tumor heterogeneity; Neuroblastoma; Wilms Tumor; Rhabdomyosarcoma; Aneuploidy;

   Abstract : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. READ MORE

6. 4. Nqabayo’s Nomansland: San Rock Art and the Somatic Past

   Author : Geoffrey Blundell; Paul Sinclair; Knut Helskog; Uppsala universitet; []
   Keywords : HUMANIORA; HUMANITIES; Archaeology; San; Bushman; southern Africa; Nomansland; Eastern Cape; Storm Shelter; rock art; shamanism; Kalahari revisionist debate; body; embodiment; somatic past; postcolonial; colonial; Arkeologi; Archaeology subjects; Arkeologiämnen;

   Abstract : The most significant challenge facing modern southern African rock art research is the integration of rock paint­ings into the construction of San history. This challenge is made all the more difficult because of poor chronologi­cal control over the images. READ MORE

7. 5. Psychological processes in somatic disease

   Author : Noomi Elander Lindberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The course of disease was investigated in three studies of patients with rheumatoid arthritis (RA). The aim was to explore changes in clinical course during and after psychodynamically oriented psychotherapy, with one session of 60-90 minutes per week for 3.3 years as a median. READ MORE