Advanced search

Showing result 1 - 5 of 69 swedish dissertations matching the above criteria.

2. 1. Somatostatin Receptor Expression and Biological Functions in Endocrine Pancreatic Cells

   Author : Eva Ludvigsen; Stellan Sandler; Eva Tiensuu Janson; Mats Stridsberg; Frank Sundler; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; somatostatin; somatostatin receptors; somatostatin analogues; NOD mouse; type 1 diabetes; pancreatic islets; BON-1 cells; Cellbiologi; Cell biology; Cellbiologi;

   Abstract : Type 1 diabetes is resulting from the selective destruction of insulin-producing beta-cells within the pancreatic islets. Somatostatin acts as an inhibitor of hormone secretion through specific receptors (sst1-5). READ MORE

4. 2. Evolution of Vertebrate Endocrine and Neuronal Gene Families : Focus on Pituitary and Retina

   Author : Daniel Ocampo Daza; Dan Larhammar; Marc Robinson-Rechavi; Uppsala universitet; []
   Keywords : phylogenetics; evolution; molecular evolution; gene family evolution; genome duplication; gene duplication; oxytocin receptor; vasopressin receptor; visual opsin; transducin; growth hormone; prolactin; somatolactin; growth hormone receptor; prolactin receptor; somatostatin receptor; SSTR; IGFBP; evolution; molekylär evolution; fylogeni;

   Abstract : The duplication of genes followed by selection is perhaps the most prominent way in which molecular biological systems gain multiplicity, diversity and functional complexity in evolution. Whole genome duplications (WGDs) therefore have the potential of generating an extraordinary amount of evolutionary innovation. READ MORE

5. 3. Theranostics in Neuroendocrine Tumors : Somatostatin Receptor Imaging and Therapy

   Author : Ezgi Ilan; Mark Lubberink; Peter Bernhardt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 177Lu-DOTATATE; 68Ga-DOTATATE; 68Ga-DOTATOC; PRRT; Theranostics; PET CT; SPECT CT; Neuroendocrine tumors; Somatostatin receptors; Medicinsk radiofysik; Medical Radiophysics;

   Abstract : Neuroendocrine tumors (NETs) are characterized by cellular overexpression of somatostatin receptors (SSTR), which allows for the use of radiolabeled somatostatin analogs (SSA) for both imaging and therapy. Because NETs often are diagnosed at a metastatic stage, curative surgery is not possible. READ MORE

6. 4. Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms : Aspects of tumour characteristics, receptor recycling and peptide mass

   Author : Ulrika Jahn; Anders Sundin; Mark Lubberink; Ulrike Garske-Román; Mona-Elisabeth Rootwelt-Revheim; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Peptide receptor radionuclide therapy PRRT ; Peptide; Small-Intestinal; Pancreatic; Dosimetry; Somatostatin receptor;

   Abstract : Neuroendocrine neoplasm (NEN) can arise in any part of the body, but most commonly in the lungs, bronchi, and the gastrointestinal tract including the pancreas. They combine neuroendocrine and tissue-of-origin-specific characteristics; explaining different symptoms depending on the organ of origin. READ MORE

7. 5. Expression and localisation of somatostatin receptor subtype 2a in neuroendocrine cells and cells of neuroectodermal origin

   Author : Sayed Hossein Hashemi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SSR2 a receptor; somatostatin; neuroendocrine tumours; tissue culture; immunocytochemistry; ; SH-SY5Y cells; CAD cell line; ependyma; tanycytes; neuronal differentiation; catecholaminergic markers; ; cholinergic markers; synaptic vesicle membrane proteins; intermediate filaments.;

   Abstract : .... READ MORE