Search for dissertations about: "somatostatin"

Showing result 1 - 5 of 110 swedish dissertations containing the word somatostatin.

  1. 1. Somatostatin Receptor Expression and Biological Functions in Endocrine Pancreatic Cells

    Author : Eva Ludvigsen; Stellan Sandler; Eva Tiensuu Janson; Mats Stridsberg; Frank Sundler; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cell biology; somatostatin; somatostatin receptors; somatostatin analogues; NOD mouse; type 1 diabetes; pancreatic islets; BON-1 cells; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Type 1 diabetes is resulting from the selective destruction of insulin-producing beta-cells within the pancreatic islets. Somatostatin acts as an inhibitor of hormone secretion through specific receptors (sst1-5). READ MORE

  2. 2. Small Intestinal Neuroendocrine Tumor Analyses : Somatostatin Analog Effects and MicroRNA Profiling

    Author : Su-Chen Li; Valeria Giandomenico; Kjell Öberg; Marco Volante; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Small intestinal neuroendocrine tumors; Somatostatin analogs; Laser-capture microdissection; Microarray profiling and microRNA profiling; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Small intestinal neuroendocrine tumors (SI-NETs) originate from serotonin-producing enterochromaffin (EC) cells in the intestinal mucosa. Somatostatin analogs (SSAs) are mainly used to control hormonal secretion and tumor growth. However, the molecular mechanisms leading to the control of SI-NETs are unknown. READ MORE

  3. 3. Expression and localisation of somatostatin receptor subtype 2a in neuroendocrine cells and cells of neuroectodermal origin

    Author : Sayed Hossein Hashemi; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ; ; SSR2 a receptor; somatostatin; neuroendocrine tumours; tissue culture; immunocytochemistry; SH-SY5Y cells; CAD cell line; ependyma; tanycytes; neuronal differentiation; catecholaminergic markers; cholinergic markers; synaptic vesicle membrane proteins; intermediate filaments.;

    Abstract : .... READ MORE

  4. 4. Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors

    Author : Maria Fridén-Saxin; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Chroman-4-ones; Chromones; Inhibitors; Molecular Modeling; Peptidomimetic; Samarium; Sirtuin; Sirt2; Somatostatin; Structure-Activity Relationships; Tubulin; β-Turn;

    Abstract : Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which make peptides hydrophilic and conformationally flexible. READ MORE

  5. 5. Growth hormone regulation of hepatic drug-metabolising enzymes in humans and rats

    Author : Eva Rasmussen; Uppsala universitet; []
    Keywords : Medical sciences; growth hormone; IGF-I; somatostatin; cytochrome P450; regulation; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : There are pronounced sex-differences in the gene expression of several liver enzymes in the rat. The sex-differentiated secretion of growth hormone (GH) regulates these differences. We wanted to further investigate the mechanisms of this regulation in rats and to study the GH regulation of drug metabolism in man. READ MORE