Search for dissertations about: "spatially-resolved transcriptomics"

Showing result 6 - 10 of 16 swedish dissertations containing the words spatially-resolved transcriptomics.

  2. 6. Image and Data Analysis for Spatially Resolved Transcriptomics : Decrypting fine-scale spatial heterogeneity of tissue's molecular architecture

    Author : Gabriele Partel; Carolina Wählby; Anna H Klemm; Mats Nilsson; Roland Eils; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; iss; image; processing; clustering; deep learning; GCN; graph;

    Abstract : Our understanding of the biological complexity in multicellular organisms has progressed at tremendous pace in the last century and even more in the last decades with the advent of sequencing technologies that make it possible to interrogate the genome and transcriptome of individual cells. It is now possible to even spatially profile the transcriptomic landscape of tissue architectures to study the molecular organization of tissue heterogeneity at subcellular resolution. READ MORE

  4. 7. Towards comprehensive cellular atlases : High-throughput cell mapping by in situ sequencing

    Author : Xiaoyan Qian; Mats Nilsson; Gunnar von Heijne; Anthony Zador; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spatially resolved transcriptomics; in situ sequencing; cell type; spatial analysis; Biochemistry; biokemi;

    Abstract : With recent technological advancements in single-cell biology, many aspects of individual cells are characterized with unprecedented resolution and details. Cell types in human and model organisms are redefined, and multiple organ-wide atlases are proposed to integrate different types of data to provide a comprehensive view of biological systems at cellular resolution. READ MORE

  5. 8. Transcriptome-wide analysis in cells and tissues

    Author : Sanja Vickovic; Afshin Ahmadian; Itai Yanai; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA-sequencing; single cells; spatially resolved transcriptomics; 3D profiling.; Biotechnology; Bioteknologi;

    Abstract : High-throughput sequencing has greatly influenced the amount of data produced and biological questions asked and answered. Sequencing approaches have also enabled rapid development of related technological fields such as single-cell and spatially resolved expression profiling. READ MORE

  6. 9. Towards spatial host-microbiome profiling

    Author : Britta Lötstedt; Joakim Lundeberg; Petri Auvinen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 16S sequencing; RNA sequencing; spatially resolved transcriptomics; antibody-based measurements; Bioteknologi; Biotechnology;

    Abstract : Sequencing technologies and applications have pushed the limits and enabled novel studies of biological mechanisms, evolutionary relationships and communication networks between cells. The technical developments leading to single cell RNA-sequencing have enabled detection of rare cell populations while spatial resolution added insights into larger biological environments, like tissues and organs. READ MORE

  7. 10. Development and application of spatial transcriptomics methods

    Author : Zaneta Andrusivova; Joakim Lundeberg; Jay W. Shin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA; Spatial Transcriptomics; RNA sequencing; Biotechnology; Bioteknologi;

    Abstract : Transcriptomics is one of the pivotal fields in molecular biology, enabling comprehensive analysis of gene expression patterns. Recent advancements in the biotechnology field have transformed the transcriptomics research, providing insights into the complexity of cellular processes in a greater detail. READ MORE