Search for dissertations about: "spermatogonia"

Showing result 1 - 5 of 11 swedish dissertations containing the word spermatogonia.

  2. 1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    Author : Suaad Meerkhan; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Abstract : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. READ MORE

  4. 2. The Xenopus tropicalis model for developmental endocrine and reproductive toxicity : Histological and molecular endpoints for disrupted spermatogenesis

    Author : Sofie Svanholm; Cecilia Berg; Oskar Karlsson; Valérie Langlois; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Reproductive toxicology; Developmental toxicology; Spermatogenesis; Transgenerational; Xenopus tropicalis; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Endocrine disrupting chemicals (EDCs) are linked to adverse effects in both humans and wildlife. There are however, large knowledge gaps regarding cause-effect and dose-response relationships between the interference with endocrine pathways and adverse effects in the organism, especially at puberty and in subsequent generations. READ MORE

  5. 3. Novel culture systems to model testicular function and organization

    Author : João Pedro Alves Lopes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In vitro systems to model the testicular microenvironment are required to study physiology and pathology of the testis, the gonadotoxic effect of environmental and pharmaceutical chemicals, as well as to explore the mechanisms ruling spermatogonial stem cell (SSC) self-renewal and differentiation. The knowledge produced in in vitro experiments, using animal, but most importantly utilizing human models, will contribute to the discovery of safe medical treatments and might provide translational tools to treat male infertility problems. READ MORE

  6. 4. Isoforms of mammalian glutaredoxin 2

    Author : Christoph Hudemann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to be involved at the interface between redox regulation, iron metabolism and iron-cluster biosynthesis. READ MORE

  7. 5. Artificial testis to study early gonadal development and germ cell differentiation

    Author : Ahmed Reda; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Studying the early germ cell development is of great significance, as germ cells transfer the genetic material between generations. However, in humans, this type of studies in vivo is not applicable, for obvious ethical reasons. READ MORE