Search for dissertations about: "spermatogonia"

Showing result 1 - 5 of 10 swedish dissertations containing the word spermatogonia.

  1. 1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    University dissertation from Medical Radiation Physics, Lund University

    Author : Suaad Meerkhan; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Abstract : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. READ MORE

  2. 2. Novel culture systems to model testicular function and organization

    University dissertation from Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Author : João Pedro Alves Lopes; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : In vitro systems to model the testicular microenvironment are required to study physiology and pathology of the testis, the gonadotoxic effect of environmental and pharmaceutical chemicals, as well as to explore the mechanisms ruling spermatogonial stem cell (SSC) self-renewal and differentiation. The knowledge produced in in vitro experiments, using animal, but most importantly utilizing human models, will contribute to the discovery of safe medical treatments and might provide translational tools to treat male infertility problems. READ MORE

  3. 3. Isoforms of mammalian Glutaredoxin 2

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Author : Christoph Hudemann; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to be involved at the interface between redox regulation, iron metabolism and iron-cluster biosynthesis. READ MORE

  4. 4. Artificial testis to study early gonadal development and germ cell differentiation

    University dissertation from Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Author : Ahmed Reda; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Studying the early germ cell development is of great significance, as germ cells transfer the genetic material between generations. However, in humans, this type of studies in vivo is not applicable, for obvious ethical reasons. READ MORE

  5. 5. In vitro models aiming for fertility preservation

    University dissertation from Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Author : Halima Albalushi; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Fertility preservation is considered a great hope to people suffering from infertility as a consequence of developmental or genetic cause, a disease itself or its treatments sequelae. In vitro models are fundamental to enrich our knowledge about human germ cell development and its regulation, to generate and screen new therapeutic measures and might provide a tool that can be transferred to clinical use to treat infertility. READ MORE