Search for dissertations about: "splicing"

Showing result 6 - 10 of 236 swedish dissertations containing the word splicing.

  2. 6. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing

    Author : Shaoan Fan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus E1B-55kDa; E4-ORF4; E4-ORF6 proteins; L1 mRNA; Polyoma virus small T antigen; regulation; transcription; splicing; PP2A; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). READ MORE

  4. 7. Regulation of HIV-1 mRNA Processing by Cellular Splicing Factors

    Author : Anna Tranell; Stefan Schwartz; Göran Akusjärvi; Ingemar Ernberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; SR protein; SRp55; SFRS6; splicing; indole derivative; Medical Virology; Medicinsk virologi;

    Abstract : According to UNAIDS there were 34 million people living with human immunodeficiency virus (HIV) infection at the end of 2010. HIV is the causative agent of acquired immunodeficiency syndrome (AIDS) and the number of people dying of AIDS-related causes at the end of 2010 was 1.8 million. READ MORE

  5. 8. Regulation of Human Papillomavirus Type 16 mRNA Splicing and Polyadenylation

    Author : Xiaomin Zhao; Stefan Schwartz; Barklie Clements; Uppsala universitet; []
    Keywords : Medical sciences; human papillomavirus type 16; gene regulation; splicing; polyadenylation; 3 UTR; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Human papillomavirus type 16 (HPV-16) is the major causative agent of cervical cancer. The life cycle of this oncogenic DNA tumour virus is strictly associated with the differentiation program of the infected epithelial cells. Expression of the viral capsid genes L1 and L2 can only be detected in the terminally differentiated epithelial cells. READ MORE

  6. 9. From 1p3 to PI3K - Studies of neuroblastoma

    Author : Susanne Fransson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; PI3K; PIK3CD; 1p36; alternative splicing; tumor; neural crest; mucosa; premalignant; tumor suppressor gene; oncogene; gene expression; epigenetics; splicing; signaling; akt; western blot; TaqMan; PIK3R1; p110H; p37H; p85; RAS;

    Abstract : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. READ MORE

  7. 10. Functional Characterization of the Cellular Protein p32 : A Protein Regulating Adenovirus Transcription and Splicing Through Targeting of Phosphorylation

    Author : Christina Öhrmalm; Göran Akusjärvi; Neus Visa; Uppsala universitet; []
    Keywords : Cell and molecular biology; Adenovirus; p32; ASF SF2; E4-ORF4; Splicing; Transcription; CTD; RNA Pol II; Cell- och molekylärbiologi;

    Abstract : Cellular processes involved in the conversion of the genetic information from DNA into a protein are often regulated by reversible phosphorylation reactions. By modulating the phosphorylated status of key proteins their activity can either be enhanced or repressed. READ MORE