Search for dissertations about: "sprague-dawley rats"

Showing result 1 - 5 of 72 swedish dissertations containing the words sprague-dawley rats.

  2. 1. Surgical Stress in Rats : The Impact of Buprenorphine on Postoperative Recovery

    Author : Renée Sundbom; Klas Abelson; Kristina Dahlborn; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgical stress; Corticosterone; Buprenorphine; Analgesia; Rats.; Försöksdjursvetenskap - Jämförande medicin; Comparative Medicine;

    Abstract : During surgery, both anesthesia and tissue damage cause physiological stress responses in the body. The hypothalamic-pituitary-adrenal (HPA) axis is activated with increased levels of glucocorticoids. READ MORE

  4. 2. Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats

    Author : Jurgita Kundrotiené; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cortical compression; cerebral ischemia; neuroprotection; hyperglycemia; GotoKakizaki rats.;

    Abstract : Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes morphological changes and neurological deficits produced by mild to moderate brain ischemia and which can be used to identify novel, potentially useful, neuroprotective agents. READ MORE

  5. 3. Computerised Microtomography : Non-invasive imaging and analysis of biological samples, with special reference to monitoring development of osteoporosis in small animals

    Author : Mats Stenström; Gudrun Alm Carlsson; Carl Carlsson; Jim Elliot; Linköpings universitet; []
    Keywords : Computed microtomography; CμT; signal-to-noise ratio SNR ; non-invasive monitoring; morphological changes; Gastrectomized Sprague-Dawley; osteoporosis; MEDICINE; MEDICIN;

    Abstract : The use of Computerised microtomography (CμT) in biomedical research is well established, with most applications developed at synchrotron facilities. The possibility to non-invasively monitor morphological changes in biological samples, makes it an attractive technique in biomedicine. READ MORE

  6. 4. Time-related Aspects of Otoprotection : Experimental Studies in Rat

    Author : Adnan Lidian; Matti Anniko; Petri Olivius; Uppsala universitet; []
    Keywords : sensorineural hearing loss; Edaravone; brain-derived neurotrophic factor; auditory brainstem response; Sprague-Dawley rat; distortion product otoacoustic emission; Pseudomonas aeruginosa exotoxin A.; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Abstract : Intratympanic injection of various otoprotectants through the round window membrane (RWM) might become available in the near future as an alternative to the currently available medical and surgical methods used to treat several inner ear diseases. The most common outcome of such diseases is sensorineural hearing loss (SNHL). READ MORE

  7. 5. Genetic differences in neuropathy and opioid responses in rats

    Author : Aleksandra Bulka; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Allodynia; genetic difference; neuropathic pain; NMDA-receptor; opioids; rat strains; pharmacokinetics; tolerance.;

    Abstract : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. READ MORE