Search for dissertations about: "sputum"

Showing result 1 - 5 of 56 swedish dissertations containing the word sputum.

2. 1. Early airway inflammation in allergic asthma : aspects of pulmonary innate immunity

   Author : Catarina Lensmar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : allergic asthma; low-dose allergen challenge; induced sputum; alveolar macrophage; cytokine; CC16; antibacterial activity; antibacterial peptide;

   Abstract : Allergic asthma is a chronic disease in which allergen-induced inflammatory processes of the airways contribute to the development of symptoms and eventually may lead to remodeling of the airway tissue. In the present work low-dose allergen inhalation challenges of individuals with asthma were used as a model to delineate inflammatory events occurring in an early phase of the allergic airway inflammation associated with asthma. READ MORE

4. 2. Airway responses to NO2 and allergen in asthmatics

   Author : Charlotte Barck; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Air pollution; nitrogen dioxide; asthma; allergic inflammation; eosinophil cationic protein; neutrophilic cells; bronchoalevolar lavage; nasal lavage; induced sputum;

   Abstract : Nitrogen dioxide (N02), a gas produced by combustion, is a common environmental air pollutant. Individuals with asthma are more sensitive to N02 exposure than healthy subjects, according to results from controlled human-exposure studies. N02 can enhance the asthmatic response to inhaled allergen. READ MORE

5. 3. Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : method development and clinical applications

   Author : Flora Gaber; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Airway inflammation; aspirin-intolerant asthma; biomarker; exhaled breath condensate; FENO; induced sputum; leukotrienes; 5-lipoxygenase; non-invasive analysis; saliva;

   Abstract : Asthma and chronic obstructive pulmonary disease (COPD) are two common diseases characterized by chronic airway inflammation, but the inflammation in asthma is different from the one in COPD. In addition, asthma is a heterogeneous disease presenting with many different phenotypes (e.g. READ MORE

6. 4. Bacterial colonisation and infection of the lower airways in cystic fibrosis : a microbiological and clinical study

   Author : Ferenc Karpati; Karolinska Institutet; Karolinska Institutet; []
   Keywords : cystic fibrosis; sputum; Pseudomonas aeruginosa; Stenotrophomonas maltophilia; Burkholderia cepacia; PCR; AP-PCR; 16S RNA gene; DNA sequencing; heterogeneity; TNF-[alpha]; IL-8; ibuprofen;

   Abstract : Pulmonary deterioration has remained the major cause of mortality in cystic fibrosis (C17) patients despite the considerable improvement of their survival due to more efficient therapy and centralised care. The progression of the CF lung disease is correlated to inflection with a limited number of colonising bacterial species. READ MORE

7. 5. Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects

   Author : Judith Bruchfeld; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Tuberculosis; HIV; Ethiopia; Mycobacterium tuberculosis; diagnosis; direct microscopy; sodium hypochlorite; sputum concentration; epidemiology; DNA drug resistance; P. carinii; PCP.;

   Abstract : The overall aim of this study was to elucidate the influence of HIV infection on the occurrence, clinical presentation, diagnostic yield and transmission of M tuberculosis among consecutive out-patients with symptoms suggestive of PTB in a high TB and HIV endemic area. Among 509 consecutive out-patients attending a university hospital in Ethiopia, 33. READ MORE