Search for dissertations about: "sr-bi"

Found 5 swedish dissertations containing the word sr-bi.

  2. 1. Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I

    Author : Magnus S.C. Johnson; Göteborgs universitet; []
    Keywords : SR-BI; HDL; Cholesterol; Scavenger receptor; Apoptosis; Ovary; Gallbladder; Peroxisome;

    Abstract : Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease. The uptake and degradation of LDL cholesterol have been characterized in detail at the molecular level. Less is known about the metabolism and cellular uptake of HDL cholesterol. READ MORE

  4. 2. Studies on scavenger receptor class B type I and genes implicated in foam cell formation

    Author : Per-Arne Svensson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scavenger receptor class B type I; high-density lipoprotein; oxidized low-density lipoprotein; macrophages; expression profiling;

    Abstract : The risk of atherosclerosis correlates with plasma levels of low-density lipoprotein (LDL) cholesterol and is inversely correlated to plasma levels of high-density lipoprotein (HDL) cholesterol. Accumulation of oxidized LDL (oxLDL) by arterial macrophages is a key event in the development of atherosclerosis. READ MORE

  5. 3. Studies on the hormonal regulation of bile acid synthesis

    Author : Thomas Lundåsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The maintenance of a normal turnover of cholesterol is of vital importance, and disturbances of cholesterol metabolism may result in several important disease conditions. The major route for the elimination of cholesterol from the body is by hepatic secretion of cholesterol and bile acids (BAs) into the bile for subsequent fecal excretion. READ MORE

  6. 4. Peptide-based delivery to glioblastoma cells studied by the blood-brain barrier model

    Author : Artita Srimanee; Ülo Langel; Ing-Marie Nilsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide-based delivery; blood-brain barrier; glioblastoma; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Crossing the blood-brain barrier (BBB) is a great challenge for delivery of highly charged macromolecules such as nucleic acids and proteins to the brain. Cell-penetrating peptides (CPPs) are promising vectors to deliver various cargoes ranging from small molecules to large molecules such as antibodies, proteins, and nucleic acids. READ MORE

  7. 5. Modulation of bile acid and cholesterol metabolism in health and disease

    Author : Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

    Abstract : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. READ MORE