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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Structure and function of the SH3 domain from Bruton´s tyrosine kinase

    Author : Henrik Hansson; KTH; []
    Keywords : nuclear magnetic resonance; src homology 3; bruton s tyrosine kinase; x-linked agammaglobulinemia; gel permeation chromatography; signal transduction;

    Abstract : .... READ MORE

  4. 2. Possible role of the receptor tyrosine kinase- and Src homology 3 domain-interacting protein Shb for apoptosis and differentiation

    Author : Torbjörn Karlsson; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  5. 3. RICH-1, a Multifunctional RhoGAP Domain-containing Protein, Involved in Regulation of the Actin Filament System and Membrane-trafficking

    Author : Ninna Richnau; Pontus Aspenström; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Rho GTPase; RhoGAP; actin; BAR domain; membrane-trafficking; formin homology proteins; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The Rho GTPases, which are related to the Ras family of proto-oncogenes, have been found to have important roles in regulating the morphogenic and migratory properties of eukaryotic cells. In addition, these proteins have been shown to regulate aspects of cell signaling, cell growth, cell division and cell survival. READ MORE

  6. 4. Signal transduction pathways involved in PDGF receptor-induced cellular responses

    Author : Roya Hooshmand-Rad; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Platelet-derived growth factor (PDGF), is a potent connective tissue cell mitogen and chemoattractant which binds to two structurally related receptors denoted PDGF α- and β- receptors. Upon binding of PDGF to the receptor, signaling molecules containing Src Homology 2 (SH2) domains are recruited to the activated receptor and mediate propagation of the signal. READ MORE

  7. 5. Molecular biology of Brouton's tyrosine kinase

    Author : Carl-Magnus Bäckesjö; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-linked agammaglobulinemia; XLA; Bruton s tyrosine kinase; Btk; signal transduction; phosphorylation; pleckstrin homology domain; PH; SH2; SH3.;

    Abstract : X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton s tyrosine kinase (Btk), a cytoplasmic enzyme related to the Src family of kinases. READ MORE