Search for dissertations about: "stage-specific expression"

Showing result 1 - 5 of 14 swedish dissertations containing the words stage-specific expression.

  2. 1. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Author : Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. READ MORE

  4. 2. Identification and characterization of progenitor populations in the human adult heart

    Author : Joakim Sandstedt; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cardiac progenitor cells; heart; C-kit; Side Population; Stage Specific Embryonic Antigens; FACS;

    Abstract : Traditionally, the heart has been regarded as a non-regenerative organ. During the last 10 years, this notion has been challenged. By 14C measurements, it was calculated that at the age of 50, about 45% of all cardiomyocytes had formed after birth. READ MORE

  5. 3. Differentiation and Pathogenicity within the Saprolegniaceae : Studies on Physiology and Gene Expression Patterns in Saprolegnia parasitica and Aphanomyces astaci

    Author : Gunnar Andersson; Michael J. Bidochka; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Zoophysiology; Zoofysiologi; Animal physiology; Zoofysiologi; fysiologisk mykologi; Physiological Mycology;

    Abstract : Saprolegnia parasitica and Aphanomyces astaci are parasitic water moulds belonging to the Oomycetes. Despite their importance as parasites they are very little studied at the molecular level and the work described in this thesis was aimed at increasing the molecular knowledge of these organisms by cloning and characterising genes of potential importance for reproduction and pathogenicity. READ MORE

  6. 4. Regulation of differentiation during the Giardia life cycle : An insight into the molecular control

    Author : Laura Rojas-López; Staffan Svärd; Marco Lalle; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Giardia; cell differentiation; encystation; histone post-translational modifications; host-parasite interaction;

    Abstract : Giardia intestinalis (syn. G. lamblia, G. duodenalis) is an intestinal protozoan parasite that causes diarrheal infections worldwide. READ MORE

  7. 5. The interplay between Giardia intestinalis and host intestinal epithelial cells : A tale of immune activation and suppression

    Author : Jana Grüttner; Staffan Svärd; Mikael E. Sellin; Steven Singer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giardia; diarrhea; RNAseq; proteomics; small intestinal epithelial cells; enteroids; organoids; protozoan; differentiation; immune response; host-parasite interaction; swimming; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Giardia intestinalis is a non-invasive, protozoan parasite causing the diarrheal disease giardiasis in a variety of mammals, including humans. The parasite has two main life cycle stages; disease-causing trophozoites and infectious cysts. Trophozoites colonize the host’s upper small intestine by attaching to intestinal epithelial cells (IECs). G. READ MORE