Search for dissertations about: "staphylococcal display"

Showing result 11 - 15 of 26 swedish dissertations containing the words staphylococcal display.

  2. 11. Generation and characterization of Affibody molecules targeting HER3

    Author : Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Keywords : Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE

  4. 12. Engineering of Affibody molecules targeting the Alzheimer’s-related amyloid β peptide

    Author : Hanna Lindberg; Stefan Ståhl; John Löfblom; Caroline Ekblad; Sara Snogerup Linse; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; Alzheimer’s disease; AD; amyloid beta; Aß; combinatorial protein engineering; staphylococcal surface display; Bioteknologi; Biotechnology;

    Abstract : .... READ MORE

  5. 13. Display of affinity proteins on bacteria and bacteriophage

    Author : Elin Gunneriusson; KTH; []
    Keywords : ;

    Abstract : Surface display of peptides and proteins on microorganismshas during the last decade gained tremendous interest due tothe numerous applications for the technique found inbiotechnology, molecular biology and immunology. This thesisdescribes both bacterial display of different affinity proteinsand display of libraries of small α-helical proteindomains on phage for selection of novel binding proteinsdenoted affibodies. READ MORE

  6. 14. Development of molecular recognition by rational and combinatorial engineering

    Author : Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE

  7. 15. Selection and use of affinity proteins developed by combinatorial engineering

    Author : Kristofer Sandström; KTH; []
    Keywords : phage display; combinatorial; selection; cd28; cllulosome; cellulose;

    Abstract : In affinity protein biotechnology the selective bindingbetween a chosen protein and an interacting biomolecule isutilized for a variety of applications including bioseparation,detection and therapy. Traditionally, affinity proteinsrecruited for such applications have been derived from naturalproteins or immunoglobulins generated via immunization routes. READ MORE