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Showing result 1 - 5 of 20 swedish dissertations matching the above criteria.
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1. Staphylococcal surface display for protein engineering and characterization
Abstract : Even though our understanding of mechanisms such as protein folding and molecular recognition is relatively poor, antibodies and alternative affinity proteins with entirely novel functions are today generated in a routine manner. The reason for this success is an engineering approach generally known as directed evolution. READ MORE
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2. Utilizing Solid Phase Cloning, Surface Display And Epitope Information for Antibody Generation and Characterization
Abstract : Antibodies have become indispensable tools in diagnostics, research and as therapeutics. There are several strategies to generate monoclonal antibodies (mAbs) in order to avoid the drawbacks of polyclonal antibodies (pAbs) for therapeutic use. READ MORE
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3. Staphylococcal surface display in directed evolution
Abstract : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. READ MORE
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4. Bacterial display systems for engineering of affinity proteins
Abstract : Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. READ MORE
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5. Staphylococcal surface display and its applications in bioscience
Abstract : Display of heterologous proteins on the surface ofmicroorganisms, enabled by means of recombinant DNA technology,has become an increasingly used strategy in variousapplications in microbiology, biotechnology and vaccinology.This thesis presents two bacterial systems, designed forsurface display of chimeric proteins on the food-gradestaphylococcal speciesStaphylococcus xylosusandStaphylococcus carnosus, respectively. READ MORE