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Showing result 1 - 5 of 92 swedish dissertations matching the above criteria.

  2. 1. Statins, HMGCR and Breast Cancer

    Author : Olöf Bjarnadottir; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Statins; HMGCR; Cyclin D1; p27; Clinical trial; Gene expressionprofiling; cholesterol-lowering medication;

    Abstract : .... READ MORE

  4. 2. Power of the Pill : Views about Cardiovascular Risk and the Risk-reducing Effect of Statins

    Author : Per Lytsy; Ragnar Westerling; Gunilla Burell; Arne Melander; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Statins; lipid-lowering drugs; cholesterol; treatment expectations; beliefs; adherence; health behaviour; Social medicine; Socialmedicin; Community pharmacy services; Samhällsfarmaci; Family medicine; Allmänmedicin; Public health science; Folkhälsovetenskap; Community medicine; Samhällsmedicin; Social Medicine; Socialmedicin;

    Abstract : Medical treatments with statins are prescribed to patients with increased risk of cardiovascular events. The benefits from statin treatment are well documented in clinical trials, but long-term adherence in patients is low, indicating that patients have an uncertainty about the necessity and benefits of treatment. READ MORE

  5. 3. Statins, Lipids, and Mutations: Consequences for the Heart and Immune System

    Author : Emil G. Ivarsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX Proteins; Statins; RHO Proteins; Dilated Cardiomyopathy;

    Abstract : CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary function. The first step in this process is called prenylation, which is the covalent attachment of a lipid, either a 15-carbon farnesyl or a 20-carbon geranylgeranyl lipid, to the carboxyl-terminal cysteine residue by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase type I (GGTase-I), respectively. READ MORE

  6. 4. Pharmacoepidemiology of Antibiotics, Weak Opioids and Statins with Special Reference to Socioeconomic Aspects - an Ecological Approach

    Author : Karin Henricson; Institutionen för hälsovetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; statins; weak opioids; antibiotics; effectiveness; socioeconomic factors; Ecologic studies; drug utilisation; farmakognosi; farmaci; toxikologi; Social medicine; Socialmedicin; samhällsmedicin;

    Abstract : The influence of socioeconomic factors on drug utilisation has been studied by pharmacoepidemiological analyses involving 1) drugs that are used to cure disease, such as antibiotics, 2) drugs that are used to alleviate symptoms, such as weak opioids, and 3) drugs that are used to prevent disease, such as statins. In a large Swedish city (Malmö), the utilisation of four major drug groups (ATC-groups A = alimentation, C = circulation, N = nervous system, and R = respiration) correlated positively with an unfavourable socioeconomic situation, most pronouncedly with group N and least so with group R. READ MORE

  7. 5. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions

    Author : Luna Prieto Garcia; Erik Sjögren; Aleksandra Galetin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiologically-Based Pharmacokinetics; Pharmacokinetics; Pharmacodynamics; Disease Modelling; Drug Interactions; Statins; Mechanistic Modelling; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. READ MORE